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Stephen J. Pandol, MD

Director, Basic and Translational Pancreas Research

Stephen J. Pandol, MD

Director, Basic and Translational Pancreas Research

  • IM/Gastroenterology

The pancreatitis-related research of Stephen J. Pandol, MD, focuses on determining the intracellular signaling (i.e., protein kinases and calcium) and organellar disorders (endoplasmic reticulum stress and mitochondrial failure) that occur during the disease. The aim is to identify what underlies the disease process and to develop treatments. For pancreatic cancer, Pandol focuses on the mechanisms of cells (i.e., stellate cells, macrophages, immune cells) that are involved in promoting the growth and metastasis of the cancer. The aim is to identify pathways these cells use to promote the cancer, with a goal of developing novel treatments, as well as preventing occurrence initially and recurrence after treatment. For diabetes, Pandol and his colleagues focus on how nutrients in the intestine activate gut endocrine cells (i.e., glucagon-like peptide-1 cells, cholecystokinin cells) to regulate glucose metabolism and food intake. The work involves identifying sensors and their functions on the gut endocrine cells with the aim of developing treatments for diabetes through agents that modulate these sensors.

  • Medical School: Saint Louis University School of Medicine, 1976
  • Residency: VA Greater Los Angeles Healthcare System, 1978
  • Fellowship: VA Greater Los Angeles Healthcare System, 1979
  • Fellowship: National Institutes of Health, 1982
  • Abrol R, Edderkaoui M, Goddard 3rd, Pandol SJ. Molecular basis for the interplay of apoptosis and proliferation mediated by Bcl-xL:Bim interactions in pancreatic cancer cells. Biochem Biophys Res Commun. 2012 Jun 15;422(4):596-601.
  • Apte MV, Wilson JS, Lugea A, Pandol SJ. A starring role for stellate cells in the pancreatic cancer microenvironment. Gastroenterology. 2013 Jun;144(6):1210-1219.
  • Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, et al. High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model. Cancer Prev Res (Phila). 2013 Oct;6(10):1064-1073.
  • Lugea A, Tischler D, Nguyen J, Gong J, Gukovsky I, French SW, Gorelick FS, Pandol SJ: Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage. Gastroenterology. 2011 Mar;140(3):987-997.
  • Lugea A, Waldron RT, French SW, Pandol SJ. Drinking and driving pancreatitis: links between endoplasmic reticulum stress and autophagy. Autophagy. 2011 Jul;7(7):783-785.
  • Pandol SJ, Gorelick FS, Lugea A. Environmental and genetic stressors and the unfolded protein response in exocrine pancreatic function - a hypothesis. Front Physiol. 2011 Mar 10;2:8.

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