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Peter Chen, MD

Director, Division of Pulmonary and Critical Care Medicine

8723 Alden Drive
Steven Spielberg Building, Suite 250
Los Angeles, CA 90048





Peter Chen, MD

Director, Division of Pulmonary and Critical Care Medicine

  • IM/Pulmonary Medicine



Chronic Obstructive Pulmonary Disease (COPD)


Interstitial Lung Diseases

Lung Cancers


With his research, Peter Chen, MD, tries to unravel basic mechanisms of lung injury and repair. His main focus is on how lung epithelial cells interact with other cellular compartments and with the extracellular matrix to regulate inflammatory cell recruitment, lung fibrosis and cancer tumorigenesis. Chen's laboratory uses cell-based and animal models in its studies and conducts translational research using clinical samples.

  • Residency: University of Texas Southwestern Medical Center, 2002
  • Fellowship: University of Washington Medical Center, 2005
  • Chair, Members in Transition and Training Committee, American Thoracic Society, 2013-current
  • Respiratory Cell and Molecular Biology Program Committee, American Thoracic Society, 2013-current
  • Editorial Board: American Journal of Respiratory Cell and Molecular Biology, 2013-current
  • VA Merit Study Section, 2012-current
  • Editorial Board: PLOS One, 2010-current
  • Jo Rae Wright Award for Outstanding Science, American Thoracic Society, 2013

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  • Altemeier WA, Schlesinger SY, Buell CA, Parks WC, Chen P. Syndecan-1 controls cell migration by activating Rap1 to regulate focal adhesion disassembly. J Cell Sci. 2012;125(Pt 21):5188-5195.
  • Chen P, Abacherli LE, Nadler ST, Wang Y, Li Q, Parks WC. MMP7 shedding of syndecan-1 facilitates re-epithelialization by affecting alpha(2)beta(1) integrin activation. PLoS ONE. 2009;4(8):e6565.
  • Chen P, Edelman JD, Gharib SA. Comparative evaluation of miRNA expression between in vitro and in vivo airway epithelium demonstrates widespread differences. Am J Pathol. 2013;183(5):1405-1410.
  • Chen P, McGuire JK, Hackman RC, Kim KH, Black RA, Poindexter K, Yan W, Liu P, Chen AJ, Parks WC, et al. Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity. Am J Pathol. 2008;172(5):1256-1270.
  • Gharib SA, Altemeier WA, Van Winkle LS, Plopper CG, Schlesinger SY, Buell CA, Brauer R, Lee V, Parks WC, Chen P. Matrix metalloproteinase-7 coordinates airway epithelial injury response and differentiation of ciliated cells. Am J Respir Cell Mol Biol. 2013;48(3):390-396.
  • Altemeier WA, Schlesinger SY, Buell CA, Brauer R, Rapraeger AC, Parks WC, Chen P. Transmembrane and extracellular domains of syndecan-1 have distinct functions in regulating lung epithelial migration and adhesion. J Biol Chem. 2012;287(42):34927-34935.

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