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Marilyn Ader, PhD

Associate Director, Diabetes & Obesity Research Institute

Associate Professor, Biomedical Sciences

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310-967-2792

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310-967-3869

Marilyn Ader, PhD

Associate Director, Diabetes & Obesity Research Institute

Associate Professor, Biomedical Sciences

The overall focus of the lab of Marilyn Ader, PhD, is the pathogenesis of Type 2 diabetes, with an integrative perspective on the impact of obesity on insulin sensitivity, insulin secretion and hepatic insulin clearance. She examines the mechanisms by which multiple organ systems interact to maintain glucose homeostasis in the face of environmental and pharmacologic insults. One of her primary projects investigates mechanisms by which antipsychotic drugs induce obesity and glucose dysregulation. These studies have had major translational and public health impact, and they involve both large-animal studies and collaborative work of psychiatric patients. Ader is a leading expert in the role of insulin-independent factors, termed "glucose effectiveness," in glucose homeostasis, and has published extensively in this area in peer-reviewed papers, book chapters and reviews. Ader also examines the role of insulin clearance in determining insulin sensitivity and fasting insulin levels, and studies the impact of obesity on the contribution of liver clearance versus pancreatic β-cell insulin secretion to fasting hyperinsulinemia. Ader is also pursuing novel pancreatic islet transplant research for possible clinical treatment of Type 1 diabetes.

  • Undergraduate: Utica College of Syracuse University, 1980
  • Master's: Kent State University, 1982
  • Doctorate: University of Southern California, 1988

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  • Ad Hoc Member, Grant Review Panels for NIH/IPOD, NIH/Endocrinology/Metabolism/Nutrition/Reproduction, NICHD, NIMH, NIA), Department of Defense, Canadian Diabetes Assoc., BUPA Foundation, 2005-13
  • Standing Member, NIH Study Section (IPOD: Integrative Physiology, Obesity, and Diabetes), 2008-13
  • Co-Editor-in-Chief, Obesity, 2011-12
  • Deputy Editor-in-Chef, Obesity, 2007-11
  • Chair, NIH Study Section (PAR: Metabolic Effects of Psychotropic Medications), 2009
  • American Diabetes Association Postdoctoral Fellowship, 1988-91
  • First Prize, Young Investigators' Forum, American Diabetes Association, 1987

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  • Bergman RN, Finegood DT, Ader M. Assessment of insulin sensitivity in vivo. Endocr. Rev. 1985;6(1):45-86.
  • Ader M, Bergman RN. Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am J Physiol. 1990;258(6 Pt 1):E1020-1032.
  • Ader M, Ni TC, Bergman RN. Glucose effectiveness assessed under dynamic and steady state conditions. Comparability of uptake versus production components. J Clin Invest. 1997;99:1187-1199.
  • Ader M, Kim SP, Catalano KJ, Ionut V, Hucking K, Richey JM, Kabir M, Bergman RN. Metabolic dysregulation with atypical antipsychotics occurs in the absence of underlying disease: a placebo-controlled study of olanzapine and risperidone in dogs. Diabetes. 2005;54(3):862-871.
  • Ader M, Stefanovski D, Kim SP, Richey JM, Ionut V, Catalano KJ, Hucking K, Ellmerer M, Van Citters G, Hsu IR, et al. Hepatic insulin clearance with attendant insulinemia is the primary determinant of insulin sensitivity in the normal dog. Obesity. 2014;22:1238-1245.
  • Ader M, Stefanovski D, Richey JM, Kim SP, Kolka CM, Ionut V, Kabir M, Bergman RN. Failure of Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) to detect marked diet-induced insulin resistance in dogs. Diabetes. 2014;63:1914-1919.

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