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Shuang Chen, MD, PhD

Assistant Professor, Pediatrics

Shuang Chen, MD, PhD

Assistant Professor, Pediatrics

The main focus of the Chen Laboratory is on understanding and modeling the mechanism of vascular inflammation, atherosclerosis and Kawasaki Disease. Shuang Chen, MD, PhD, has developed his research interests in understanding and modeling the mechanism of cardiovascular disease starting from his post doctorate training in China. Since he joined the laboratory of Moshe Arditi, MD, in 2004 at the Cedars-Sinai, his focus has been on investigating the role of TLRs and Innate Immunity in hypercholesterolemic mouse models of atherosclerosis, as well as the role of these innate immune receptors on Chlamydophila pneumoniae-induced acceleration of atherosclerosis. Chen has made strong contributions towards generating the ApoE/TLR4 and ApoE/MyD88 double KO mice and the measurement of atherosclerosis in these double knockouts. He has also developed new approaches that allowed to isolate and culture aortic and lung microvessel endothelial cells from these various TLR pathway KO mice. Chen has published 42 papers since 2005, and presented his studies in national meetings. Chen has vast experience with the proposed mouse model of coronary arteritis, the best model of Kawasaki Disease, and has made significant contributions to the field with four papers he has written. He has obtained his first independent grant from AHA for three years to investigate the role of NOD/Rip2 pathway and IL-17 A in atherosclerosis and in Infection-accelerated atherosclerosis in 2009-2012. With this support, Chen has gotten more publications on Role of IL-17 and atherosclerosis, which was the first direct evidence that IL-17A plays a proatherogenic role in mice. He was appointed as assistant professor of pediatrics and biomedical sciences. Chen has obtained a RO1 from NHLBI in 2012. His future research will focus on the immunology and atherosclerosis and Kawasaki disease study to conduct and publish high quality research.

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