Zhaohui Chen, PhD

Assistant Professor, Medicine

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Zhaohui Chen, PhD

Assistant Professor, Medicine

Research in the Chen Laboratory focuses on translating the discovery and validation of state of art mass spectrometry technologies to evaluate potential treatments for patients affected by diseases, such as cardiovascular disease and kidney disease. In order to understand the mechanism of action and assess the effects of therapies, Chen Lab has developed robust mass spectrometry-based platforms to fingerprint and measure the changes in diseases in an increasing number of samples, including quantification from small molecule metabolites to large proteins and their disease-induced modified forms.

  • Doctorate: University of Alberta, 2001
  • Chen DZ, Caulfield MP, McPhaul MJ, Reitz RE, Taylor SW, Clarke NJ. Quantitative Insulin Analysis using Liquid Chromatography-Tandem Mass Spectrometry in a High-throughput Clinical Laboratory. Clin Chem. 2013;59(9):1349-1356.
  • Fu Q, Chen Z, Zhang S, Parker S, Fu Z, Tin A, Liu X, Van Eyk JE. Multiple and selective reaction monitoring using triple quadrupole mass spectrometer: preclinical large cohort analysis. Methods Mol Biol. 2016;1410:249-264.
  • Sheng S, Chen D, Van Eyk JE. Multidimensional liquid chromatography separation of intact proteins by chromatographic focusing and reversed phase of the human serum proteome: optimization and protein database. Mol Cell Proteomics. 2006;5(1):26-34.
  • Liang L, Woodward OM, Chen DZ, Cotter R, Guggino WB. A novel role of protein tyrosine kinase2 in mediating chloride secretion in human airway epithelial cells. PLoS One. 2011;6(7):e21991.
  • Jia Y, Wu T, Jelinek C, Bielekova B, Chang L, Newsome S, Gnanapavan S, Giovannoni G, Chen D, Calabresi P, et al. Development of protein biomarkers in cerebrospinal fluid for secondary progressive multiple sclerosis using selected reaction monitoring mass spectrometry (SRM-MS). Clin Proteomics. 2012;9(1):9.

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