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Vera Chesnokova, PhD

Associate Professor, Medicine

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Vera Chesnokova, PhD

Associate Professor, Medicine

The research of Vera Chesnokova, PhD, focuses on the molecular and physiological mechanism of pituitary tumor development and the role of pituitary cell senescence in tumor growth. She found that expression of senescence-associated proteins restrains pituitary tumor development in mice and may underlie slow growth of pituitary tumors in humans. Chesnokova also is studying the role of pituitary and local growth hormone in colon tumor development. Her research showed that growth hormone suppresses major tumor suppressor proteins, including p53, PTEN and APC, creating a pro-tumorigenic environment in the colon. Her current research also includes mechanisms of neurogenesis in the adult hippocampus and the role of pro-inflammatory cytokines in new neuron and glia development in the human and murine brain. She studies the role of cell cycle proteins in the generation of new neurons and mechanisms underlying stimulation of adult neurogenesis by antidepressants. Chesnokova's research showed that cell cycle inhibitor p21 plays a key role in restraining neuronal proliferation in the hippocampus and that the action of antidepressants on neurogenesis occurs via p21 suppression.

View NIH Biographical Sketch as a PDF

  • Undergraduate: Novosibirsk State University, 1973
  • Doctorate: Institute of Cytology and Genetics, 1983
  • Member, Institutional Animal Care and Use Committee, 2003-present
  • Editorial Board: Frontiers in Endocrinology, Pituitary, Current
  • Editorial Board: Frontiers in Systems and Translational Endocrinology, Current
  • Independent Investigator Award, NARSAD, 2009
  • Young Investigator Award, NARSAD, 2003
  • Young Investigator Award, Cedars-Sinai, 1999

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Click here for a list of peer-reviewed publications.

  • Chesnokova V, Zhou C, Ben-Shlomo A, Zonis S, Tani Y, Ren SG, Melmed S. Growth hormone is a cellular senescence target in pituitary and nonpituitary cells. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):E3331-3339.
  • Zonis S, Ljubimov VA, Mahgerefteh M, Pechnick RN, Wawrowsky K, Chesnokova V. p21Cip restrains hippocampal neurogenesis and protects neuronal progenitors from apoptosis during acute systemic inflammation. Hippocampus. 2013 Dec;23(12):1383-1394.
  • Zonis S, Pechnick RN, Ljubimov VA, Mahgerefteh M, Wawrowsky K, Michelsen KS, Chesnokova V. Chronic intestinal inflammation alters hippocampal neurogenesis. J Neuroinflammation. 2015 Apr 3;12:65.
  • Chesnokova V, Pechnick RN. New Signaling Pathway for Gut-Brain Interactions. Neuropsychopharmacology. 2016 Jan;41(1):372-373.
  • Chesnokova V, Pechnick RN, Wawrowsky K. Chronic peripheral inflammation, hippocampal neurogenesis, and behavior. Brain Behav Immun. 2016 Nov;58:1-8.
  • Chesnokova V, Zonis S, Zhou C, Recouvreux MV, Ben-Shlomo A, Araki T, Barrett R, Workman M, Wawrowsky K, Ljubimov VA. Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3250-3259.

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