Mouad Edderkaoui, PhD

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Mouad Edderkaoui, PhD

The research goal of Mouad Edderkaoui, PhD, is to understand the mechanism of pancreatic cancer initiation and progression and to develop a treatment strategy for the disease. Edderkaoui focuses on the role of cells present in the tumor microenvironment and how histone deacetylases (HDACs) regulate the interaction between these cells.

  • Associate Editor: Frontiers in Science, Current
  • Hirshberg Foundation Award, 2012
  • American Pancreatic Association, 2011
  • Career Development Award, National Institutes of Health, 2011
  • American Association for Cancer Research, 2008
  • Edderkaoui M, Hong P, Lee JK, Pandol SJ, Gukovskaya AS. Insulin-like growth factor-I receptor mediates the prosurvival effect of fibronectin. J Biol Chem. 2007 Sep 14;282(37):26646-26655.
  • Edderkaoui M, Lugea A, Hui H, Eibl G, Lu QY, Moro A, Lu X, Li G, Go VL, Pandol SJ. Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells. Nutr Cancer. 2013;65(8):1232-1244.
  • Edderkaoui M, Nitsche C, Zheng L, Pandol SJ, Gukovsky I, Gukovskaya AS. NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox. J Biol Chem. 2011 Mar 11;286(10):7779-7787.
  • Nitsche C, Edderkaoui M, Moore RM, Eibl G, Kasahara N, Treger J, Grippo PJ, Mayerle J, Lerch MM, Gukovskaya AS. The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation. Gastroenterology. 2012 Feb;142(2):377-387.e1-5.
  • Pandol SJ, Apte MV, Wilson JS, Gukovskaya AS, Edderkaoui M. The burning question: why is smoking a risk factor for pancreatic cancer? Pancreatology. 2012 Jul-Aug;12(4):344-349.
  • Park CH, Lee IS, Grippo P, Pandol SJ, Gukovskaya AS, Edderkaoui M. Akt kinase mediates the prosurvival effect of smoking compounds in pancreatic ductal cells. Pancreas. 2013 May;42(4):655-662.

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