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Helen Goodridge, PhD

Assistant Professor, Medicine

Assistant Professor, Biomedical Sciences

Director, Postdoctoral Scientist Program, Cedars-Sinai Medical Center

Research Scientist, Regenerative Medicine Institute

Email:

helen.goodridge@csmc.edu

Research Office:

Phone:

310-248-8577

Helen Goodridge, PhD

Assistant Professor, Medicine

Assistant Professor, Biomedical Sciences

Director, Postdoctoral Scientist Program, Cedars-Sinai Medical Center

Research Scientist, Regenerative Medicine Institute

Neutrophils, macrophages and dendritic cells are key players in innate immunity and inflammation. The lab is characterizing the mechanisms that regulate the production of these cells (myelopoiesis), the signals that instruct their responses to microbial components and other "danger signals", and the roles of these cells in antimicrobial immunity, inflammatory disease, neurodegenerative disease, cancer and aging.

  • Undergraduate: University of Cambridge, UK, 1997
  • Doctorate: University of Glasgow, UK, 2001
  • UCLA Clinical and Translational Science Institute Recognition Award, 2012
  • Promega Young Immunologist of the Year, 2002

Click here for a list of peer-reviewed publications.

  • Yanez A, Ng MY, Hassanzadeh-Kiabi N, Goodridge HS. IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil versus monocyte production. Blood. 2015;125(9):1452-1459.
  • Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, et al. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 2011;472(7344):471-475.
  • Khosravi A, Yanez A, Price JG, Chow A, Merad M, Goodridge HS, Mazmanian SK. Gut microbiota promote hematopoiesis to control bacterial infection. Cell Host Microbe. 2014;15(3):374-381.
  • Goodridge HS. Induced pluripotent stem cell-derived myeloid phagocytes: disease modeling and therapeutic applications. Drug Discov Today. 2014;19(6):774-780.
  • Yanez A, Hassanzadeh-Kiabi N, Ng MY, Megias J, Subramanian A, Liu GY, Underhill DM, Gil ML, Goodridge HS. Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce. Eur J Immunol. 2013;43(8):2114-2125.
  • Underhill DM, Goodridge HS. Information processing during phagocytosis. Nat Rev Immunol. 2012;12:492-502.

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