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Helen Goodridge, PhD

Associate Professor, Biomedical Sciences

Associate Professor, Medicine

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Helen Goodridge, PhD

Associate Professor, Biomedical Sciences

Associate Professor, Medicine

Helen Goodridge, PhD, is an immunologist whose research focuses on neutrophils, macrophages and dendritic cells, which are key players in innate immunity and inflammation. The Goodridge lab is characterizing the mechanisms that regulate the production of these cells (myelopoiesis), the signals that instruct their responses to microbial components and other "danger signals," and the roles of these cells in antimicrobial immunity, inflammatory disease, neurodegenerative disease, cancer and aging.

  • Undergraduate: University of Cambridge, 1997
  • Doctorate: University of Glasgow, 2001
  • Promega Young Immunologist of the Year, 2002
  • UCLA Clinical and Translational Science Institute Recognition Award, 2012
  • Cedars-Sinai Postdoctoral Scientist Program Recognition Award, 2015
  • Dr. David L. Rimoin Teaching Excellence Award, Cedars-Sinai Graduate Program in Biomedical Science and Translational Medicine, 2016

Click here for a list of peer-reviewed publications.

  • Yáñez A, Coetzee SG, Olsson A, Muench DE, Berman BP, Hazelett DJ, Salomonis N, Grimes HL, Goodridge HS. Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes. Immunity. 2017;47(5):890-902
  • Hassanzadeh-Kiabi N, Yáñez A, Dang I, Martins GA, Underhill DM, Goodridge HS. Autocrine Type I IFN Signaling in Dendritic Cells Stimulated with Fungal β-Glucans or Lipopolysaccharide Promotes CD8 T Cell Activation. J Immunol. 2017;198(1):375-382.
  • Yáñez A, Ng MY, Hassanzadeh-Kiabi N, Goodridge HS. IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil versus monocyte production. Blood. 2015;125(9):1452-1459.
  • O'Rourke JG, Bogdanik L, Yáñez A, Lall D, Wolf AJ, Muhammad AK, Ho R, Carmona S, Vit JP, Zarrow J, Kim KJ, Bell S, Harms MB, Miller TM, Dangler CA, Underhill DM, Goodridge HS, Lutz CM, Baloh RH. C9orf72 is required for proper macrophage and microglial function in mice. Science. 2016;351(6279):1324-1329.
  • Goodridge HS, Ahmed SS, Curtis N, Kollmann TR, Levy O, Netea MG, Pollard AJ, van Crevel R, Wilson CB. Harnessing the beneficial heterologous effects of vaccination. Nat Rev Immunol. 2016. Nat Rev Immunol. 2016;16(6):392-400.
  • Khosravi A, Yáñez A, Price JG, Chow A, Merad M, Goodridge HS, Mazmanian SK. Gut microbiota promote hematopoiesis to control bacterial infection. Cell Host Microbe. 2014;15(3):374-381.
  • Yáñez A, Hassanzadeh-Kiabi N, Ng MY, Megias J, Subramanian A, Liu GY, Underhill DM, Gil ML, Goodridge HS. Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce. Eur J Immunol. 2013;43(8):2114-2125.
  • Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, et al. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 2011;472(7344):471-475.

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