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Helen Goodridge, PhD

Assistant Clinical Professor, Artherioschlerosis Research Center

Assistant Clinical Professor, Digestive and Liver Diseases

Associate Professor, Biomedical Sciences and Medicine

Research Scientist, Board of Governors Regenerative Medicine Institute

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Helen Goodridge, PhD

Assistant Clinical Professor, Artherioschlerosis Research Center

Assistant Clinical Professor, Digestive and Liver Diseases

Associate Professor, Biomedical Sciences and Medicine

Research Scientist, Board of Governors Regenerative Medicine Institute

Helen Goodridge, PhD, is an immunologist whose research focuses on neutrophils, macrophages and dendritic cells, which are key players in innate immunity and inflammation. The Goodridge lab is characterizing the mechanisms that regulate the production of these cells (myelopoiesis), the signals that instruct their responses to microbial components and other "danger signals," and the roles of these cells in antimicrobial immunity, inflammatory disease, neurodegenerative disease, cancer and aging.

  • Undergraduate: University of Cambridge, 1997
  • Doctorate: University of Glasgow, 2001
  • Promega Young Immunologist of the Year, 2002
  • UCLA Clinical and Translational Science Institute Recognition Award, 2012
  • Cedars-Sinai Postdoctoral Scientist Program Recognition Award, 2015
  • Dr. David L. Rimoin Teaching Excellence Award, Cedars-Sinai Graduate Program in Biomedical Science and Translational Medicine, 2016

Click here for a list of peer-reviewed publications.

  • Hassanzadeh-Kiabi N, Yáñez A, Dang I, Martins GA, Underhill DM, Goodridge HS. Autocrine Type I IFN Signaling in Dendritic Cells Stimulated with Fungal β-Glucans or Lipopolysaccharide Promotes CD8 T Cell Activation. J Immunol. 2017 Jan 1;198(1):375-382.
  • Goodridge HS, Ahmed SS, Curtis N, Kollmann TR, Levy O, Netea MG, Pollard AJ, van Crevel R, Wilson CB. Harnessing the beneficial heterologous effects of vaccination. Nat Rev Immunol. 2016. Nat Rev Immunol. 2016 Jun;16(6):392-400.
  • O'Rourke JG, Bogdanik L, Yáñez A, Lall D, Wolf AJ, Muhammad AK, Ho R, Carmona S, Vit JP, Zarrow J, Kim KJ, Bell S, Harms MB, Miller TM, Dangler CA, Underhill DM, Goodridge HS, Lutz CM, Baloh RH. C9orf72 is required for proper macrophage and microglial function in mice. Science. 2016;351(6279):1324-1329.
  • Yáñez A, Ng MY, Hassanzadeh-Kiabi N, Goodridge HS. IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil versus monocyte production. Blood. 2015;125(9):1452-1459.
  • Khosravi A, Yáñez A, Price JG, Chow A, Merad M, Goodridge HS, Mazmanian SK. Gut microbiota promote hematopoiesis to control bacterial infection. Cell Host Microbe. 2014;15(3):374-381.
  • Yáñez A, Hassanzadeh-Kiabi N, Ng MY, Megias J, Subramanian A, Liu GY, Underhill DM, Gil ML, Goodridge HS. Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce. Eur J Immunol. 2013;43(8):2114-2125.
  • Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, et al. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 2011;472(7344):471-475.

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