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Roberta Gottlieb, MD

Assistant Clinical Professor, Artherioschlerosis Research Center

Director, Molecular Cardiobiology

Dorothy and E. Phillip Lyon Chair in Molecular Cardiology in honor of Clarence M. Agress MD

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424-315-2867

Roberta Gottlieb, MD

Assistant Clinical Professor, Artherioschlerosis Research Center

Director, Molecular Cardiobiology

Dorothy and E. Phillip Lyon Chair in Molecular Cardiology in honor of Clarence M. Agress MD

The research of Roberta Gottlieb, MD, focuses on myocardial ischemia and cardioprotection. Her focus is on mitochondria and autophagy, using biochemistry, microscopy, and molecular physiology tools in cell, rodent, and porcine models to understand and mitigate ischemic injury with a goal of developing therapeutics for use in humans.

  • Undergraduate: Johns Hopkins University, 1980
  • Medical School: Johns Hopkins University School of Medicine, 1984
  • Frontiers in Biology, Current
  • Journal of Molecular and Cellular Cardiology, Current
  • San Diego Women Who Mean Business, 2012
  • Fellow of the American Heart Association, 2010
  • Overall Winner, SD Tech Coast Angels Quick Pitch, 2009
  • Fellow of the International Society for Heart Research, 2009
  • Biochemical Journal, 2004-08
  • American Journal of Physiology: Cellular Physiology, 2003-05
  • Pew Scholar in Biomedical Sciences, 1997-2000
  • International Society for Heart Research, 1996
  • American Heart Association, 1994

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  • Hernandez G, Thornton C, Stotland A, Lui D, Sin J, Ramil J, Magee N, Andres A, Quarato G, Carreira RS, Sayen MR, Wolkowicz R, Gottlieb RA. MitoTimer: A novel tool for monitoring mitochondrial turnover. Autophagy. 2013;9(11):1852-61.
  • Huang C, Andres AM, Ratliff EP, Hernandez G, Lee P, Gottlieb RA. Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1. PLoS ONE. 2011;6(6):e20975.
  • Andres AM, Stotland A, Queliconi BB, Gottlieb RA. A time to reap, a time to sow: Mitophagy and biogenesis in cardiac pathophysiology. J Mol Cell Cardiol. 2015;78:62-72.
  • Gottlieb RA, Andres AM, Sin J, Taylor DPJ. Untangling autophagy measurements: all fluxed up. Circ Research. 2015;116:504-514.
  • Sin J, Andres AM, Taylor DJR, Weston T, Hiraumi Y, Stotland A, Kim B, Huang C, Doran K, Gottlieb RA. Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts. Autophagy. 2015 Nov 13:0. PMID: 26566717.
  • Andres A, Tucker KC, Thomas A, Taylor DJR, Sengstock D, Jahania SM, Dabir R, Pourpirali S, Brown JA, Westbrook DG, Ballinger SW, Mentzer RM Jr., Gottlieb, RA. Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass. JCI Insight. 2017 Feb 23;2(4):e89303.

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