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Lali Medina-Kauwe, PhD

Associate Professor, Biomedical Sciences

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310-423-7339

Lali Medina-Kauwe, PhD

Associate Professor, Biomedical Sciences

The research of Lali Medina-Kauwe, PhD, focuses on using the cell penetration functions of pathogen proteins to develop novel cell-targeted nanotherapeutics. She is studying protein-host cell interactions, including endocytic routing, to direct the design of our nanoparticles for improved therapy. She is also currently testing these particles for cancer targeting and treatment.

  • Doctorate: UCLA, 1995
  • U.S. Patent No. 9,078,927, "Self-Assembling Complex For Targeting Chemical Agents To Cells", 2015
  • Co-Founder and Acting Chief Scientific Officer, Eos Biosciences, 2014-present
  • The David L. Rimoin Excellence in Teaching Award, 2013, 2014
  • Profiled Researcher, International Innovation Healthcare Journal, 2011, 2012
  • Guest Editor: Gene Therapy, 2004-05
  • Phi Beta Kappa, 1989-2005
  • National Cancer Institute CURE Award, 2003

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  • Sims JD, Hwang JY, Wagner S, Alonso-Valenteen F, Hanson C, Taguiam JM, Polo R, Harutyunyan I, Karapetyan G, Sorasaenee K, Ibrahim A, Marban E, Moats R, Gray HB, Gross Z, Medina-Kauwe LK. A corrole nanobiologic elicits tissue-activated MRI contrast enhancement and tumor-targeted toxicity. J Control Release. 2015;217:92-101.
  • Agadjanian H, Chu D, Hwang JY, Wachsmann-Hogiu S, Rentsendorj A, Song L, Valluripalli V, Lubow J, Ma J, Sharifi B, Farkas DL, Medina-Kauwe LK. Chemotherapy targeting by DNA capture in viral protein particles. Nanomedicine. 2012;7(3):335-352.
  • Agadjanian H, Ma J, Rentsendorj A, Valluripalli V, Hwang JY, Mahammed A, Farkas DL, Gray HB, Gross Z, Medina-Kauwe LK. Tumor detection and elimination by a targeted gallium corrole. Proc Natl Acad Sci USA. 2009;106(15):6105-6110.
  • Medina-Kauwe LK. "Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? Adv Drug Deliv Rev. 2007;59(8):798-809.
  • Xie J, Chiang L, Contreras J, Wu K, Garner JA, Medina-Kauwe L, Hamm-Alvarez SF. Novel fiber-dependent entry mechanism for adenovirus serotype 5 in lacrimal acini. J Virol. 2006;80(23):11833-11851.
  • Medina-Kauwe LK. Endocytosis of adenovirus and adenovirus capsid proteins. Adv Drug Deliv Rev. 2003;55(11):1485-1496.

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