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Kathrin Michelsen, PhD

Assistant Professor, Medicine

Research Scientist, Inflammatory Bowel Disease Center

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Research Office:

Phone:

310-423-0359

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310-423-0224

Kathrin Michelsen, PhD

Assistant Professor, Medicine

Research Scientist, Inflammatory Bowel Disease Center

The research of Kathrin Michelsen, PhD, focuses on the role of innate and adaptive immunity in the development of intestinal inflammation. Animal models are used to elucidate the molecular mechanism of dysregulated immune responses that lead to chronic inflammation of the mucosa. The mouse models of intestinal inflammation are used as pre-clinical models to conduct laboratory studies that will identify molecules for eventual therapeutic intervention.

  • Doctorate: Humboldt University of Berlin, 2002
  • Society for Mucosal Immunology, 2011
  • UCLA Chancellor's Award for Postdoctoral Research, 2005
  • International Endotoxin and Innate Immunity Society, 2004
  • American Association of Immunologists, 2003

Click here for a list of peer-reviewed publications.

  • Michelsen KS, Arditi M. Toll-like receptor signaling and atherosclerosis. Curr Opin Hematol. 2006;13(3):163-168.
  • Michelsen KS, Arditi M. Toll-like receptors and innate immunity in gut homeostasis and pathology. Curr Opin Hematol. 2007;14(1):48-54.
  • Michelsen KS, Wong MH, Shah PK, Zhang W, Yano J, Doherty TM, Akira S, Rajavashisth TB, Arditi M. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U.S.A. 2004;101(29):10679-10684.
  • Prehn JL, Thomas LS, Landers CJ, Yu QT, Michelsen KS, Targan SR. The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells. J Immunol. 2007;178(7):4033-4038.
  • Chen S, Wong MH, Schulte DJ, Arditi M, Michelsen KS. Differential expression of Toll-like receptor 2 (TLR2) and responses to TLR2 ligands between human and murine vascular endothelial cells. J Endotoxin Res. 2007;13(5):281-296.
  • Takedatsu H, Michelsen KS, Wei B, Landers CJ, Thomas LS, Dhall D, Braun J, Targan SR. TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology. 2008;135(2):552-567.
  • Michelsen KS, Wong MH, Ko B, Thomas LS, Dhall D, Targan SR. HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses. Inflamm Bowel Dis. 2013;19(1):151-164.

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