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Michela Ottolia, PhD

Associate Professor, Medicine

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Michela Ottolia, PhD

Associate Professor, Medicine

The laboratory of Michela Ottolia, PhD, studies the mechanisms of operation of ion channels and transporters to understand their function in healthy and diseased hearts. The cardiac sodium-calcium exchanger is central to the lab's research interests. Lab members are investigating the exchanger's mechanisms of transport and regulation by cytosolic calcium, sodium and protons to determine how they influence heart contractility. The main tools used within the laboratory include leading-edge optical techniques combined with state-of-the-art electrophysiology and molecular biology.

  • Member, American Heart Association study section, 2009-present
  • Grant-In-Aid, American Heart Association, 2014-16
  • Beginning Grant-In-Aid, American Heart Association, 2003-05
  • Travel Award, UCLA Department of Physiology, 2000
  • Postdoctoral Fellowship, American Heart Association, 1998-2000
  • Postdoctoral Fellowship, National Council of Research, Italy, 1996-97
  • Member, Biophysical Society
  • Member, Cardiac Muscle Society

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Click here for a list of peer-reviewed publications.

  • Ottolia M, Nicoll DA, Philipson KD. Roles of two Ca2+-binding domains in regulation of the cardiac Na+-Ca2+ exchanger. J Biol Chem. 2009;284(47):32735-32741.
  • John SA, Ribalet B, Weiss JN, Philipson KD, Ottolia M. Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers. Proc Natl Acad Sci U.S.A. 2011;108(4):1699-1704.
  • John SA, Liao J, Jiang Y, Ottolia M. The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways. Proc Natl Acad Sci U.S.A. 2013;110(8):7500-7555.

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