FOR PREVIEW ONLY (Print)

William Parks, PhD

Executive Vice Chair, Research Department of Medicine

Professor, Medicine

Scientific Director, Women's Guild Lung Institute

Send an Email

Research Office:

Phone:

424-315-4307

William Parks, PhD

Executive Vice Chair, Research Department of Medicine

Professor, Medicine

Scientific Director, Women's Guild Lung Institute

The research of William Parks, PhD, focuses on the role of matrix metalloproteinases (MMPs) in immunity, tissue repair, and fibrosis. With an emphasis on models of lung and skin diseases, his lab has determined that individual MMPs control distinct, non-overlapping functions in antimicrobial defense, epithelial repair and differentiation, leukocyte influx and activation, and resolution of fibrosis.

View NIH Biographical Sketch as a PDF

  • Doctorate: Medical College of Wisconsin, 1982
  • Post Doctorate: Michigan State University, 1984
  • Post Doctorate: Washington University School of Medicine, 1985
  • Associate Editor:Matrix Biology, Current
  • Associate Editor: American Journal of Pathology, Current
  • Consulting Editorial Board: Journal of Clinical Investigation, Current
  • Deputy Editor: American Journal of Respiratory Cell and Molecular Biology, 2015-16
  • Scientific Achievement Award, American Thoracic Society, 2015
  • Founding Editor: Metalloproteinases in Medicine, 2013-15
  • Founding Editor: Journal of Inflammation Research, 2009-13
  • Endowed Chair in Pulmonary Disease Research, University of Washington, 2011
  • Lester I. Conrad Foundation Research Award in Dermatology, 1997
  • Genentech Scholar/American Lung Association Career Investigator Award, 1993

Show moreShow less

  • McMahan RS, Birkland TP, Smigiel KS, Vandivort TC, Rohani MG, Manicone AM, McGuire JK, Gharib S, Parks WC. Stromelysin-2 (MMP10) moderates inflammation by controlling macrophage activation. J Immunol. 2016;197(3):899-909.
  • Gill SE, Nadler ST, Li Q, Park PW, Frevert CW, Chen P, Parks WC. Shedding of Syndecan-1/CXCL1 Complexes by Matrix Metalloproteinase 7 Functions as an Epithelial Checkpoint of Neutrophil Activation. Am J Respir Cell Mol Biol. 2016;55(2):243-251.
  • Secor PR, Sweere J, Michaels LA, Malkovskiy AV, Lazzareschi D, Katznelson E, Arrigoni A, Braun KR, Evanko SP, Kaminsky W, Singh PK, Parks WC*, et al. Filamentous bacteriophage promote biofilm assembly and function. Cell Host Microbe. 2015;18(5):549-559. *Co-senior authors
  • Rohani MG, McMahan RS, Hurtz AL, Razumova MV, Cieslewicz M, Pun SH, Wang Y, Birkland TP, Parks WC. Stromelysin-2 (MMP-10) regulates the collagenolytic activity of alternatively activated resident macrophages. J Invest Dermatol. 2015;135:2377-2384.
  • Parks WC, Wilson CL, Lopez-Boado YS. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol. 2004;4(8):617-629.
  • Li Q, Park PW, Wilson CL, Parks WC. Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Cell. 2002;111(5):635-646.
  • Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, Lopez-Boado YS, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science. 1999;286(5437):113-117.

Show moreShow less

Many of the physicians who have medical staff privileges to practice medicine at Cedars-Sinai Medical Center are independent physicians, and not employees or agents of the hospital. These independent physicians bill separately for their services. You should contact your physician to determine their status and billing practices.

Send Email to William Parks, PhD