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William Parks, PhD

Executive Vice Chair, Research Department of Medicine

Professor, Medicine

Scientific Director, Women's Guild Lung Institute

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424-315-4307

William Parks, PhD

Executive Vice Chair, Research Department of Medicine

Professor, Medicine

Scientific Director, Women's Guild Lung Institute

The research of William Parks, PhD, focuses on the role of matrix metalloproteinases (MMPs) in immunity, tissue repair, and fibrosis. With an emphasis on models of lung and skin diseases, his lab has determined that individual MMPs control distinct, non-overlapping functions in antimicrobial defense, epithelial repair and differentiation, leukocyte influx and activation, and resolution of fibrosis.

  • Doctorate: Medical College of Wisconsin, 1982
  • Post Doctorate: Michigan State University, 1984
  • Post Doctorate: Washington University School of Medicine, 1985

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  • Deputy Editor: American Journal of Respiratory Cell and Molecular Biology, Current
  • Associate Editor: American Journal of Pathology, Current
  • Consulting Editorial Board: Journal of Clinical Investigation, Current
  • Scientific Achievement Award, American Thoracic Society, 2015
  • Editor: Metalloproteinases in Medicine, 2013-15
  • Editor: Journal of Inflammation Research, 2009-13
  • Endowed Chair in Pulmonary Disease Research, University of Washington, 2011
  • Triangle Area Pulmonary Scholar, Duke University, 2008
  • Lester I. Conrad Foundation Research Award in Dermatology, 1997
  • Genentech Scholar/American Lung Association Career Investigator Award, 1993

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  • Gill SE, Gharib SA, Bench EM, Sussman SW, Wang RT, Rims C, Birkland TP, Wang Y, Manicone AM, McGuire JK, Parks WC. Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages. Am J Respir Cell Mol Biol. 2013;49(5):768-777.
  • Li Q, Park PW, Wilson CL, Parks WC. Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Cell. 2002;111(5):635-646.
  • Manicone AM, Birkland TP, Lin M, Betsuyaku T, van Rooijen N, Lohi J, Keski-Oja J, Wang Y, Skerrett SJ, Parks WC. Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia. J Immunol. 2009;182(6):3866-3876.
  • Parks WC, Wilson CL, Lopez-Boado YS. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol. 2004;4(8):617-629.
  • Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, Lopez-Boado YS, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science. 1999;286(5437):113-117.
  • Rohani MG, McMahan RS, Hurtz AL, Razumova MV, Cieslewicz M, Pun SH, Wang Y, Birkland TP, Parks WC. Stromelysin-2 (MMP-10) regulates the collagenolytic activity of alternatively activated resident macrophages. J Invest Dermatol. 2015;135:2377-2384.
  • Secor PR, Sweere J, Michaels LA, Malkovskiy AV, Lazzareschi D, Katznelson E, Arrigoni A, Braun KR, Evanko SP, Kaminsky W, Singh PK, Parks WC*, Bollyky PL*. 2015. Filamentous bacteriophage promote biofilm assembly and tolerance to desiccation and antibiotics. Cell Host Microbe. [Epub ahead of print]. (*co-senior authors)

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