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Gadi Pelled, PhD

Assistant Professor, Surgery

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Gadi Pelled, PhD

Assistant Professor, Surgery

Novel therapeutic platforms based on biological therapies are required to overcome extensive skeletal tissue loss or degeneration and replace the currently used synthetic prostheses. Complex clinical challenges such as intervertebral disc degeneration, osteoporotic vertebral fractures, tendon and ligament injuries, nonunion fractures and osteoarthritis pose a great challenge to health systems and to clinicians. Gadi Pelled, PhD, has been investigating the use of adult mesenchymal stem cells (MSCs) for skeletal tissue regeneration. His studies have shown that MSCs were able to regenerate skeletal tissues such as bone and tendon. Moreover, Pelled has shown, using state-of-the-art nanotechnological tools, that engineered bone generated by MSCs has chemical, topographical and nanomechanical properties similar to those of natural mature bone. State-of-the-art technologies are needed to promote tissue regeneration and monitor the effect of stem cell implantation. Pelled has used dynamic culture systems in his studies to investigate the feasibility of growing bone tissue in the lab. In addition, he has developed a novel imaging-based method to analyze tissue mechanics in vivo.

View NIH Biographical Sketch as a PDF

  • Undergraduate: Hebrew University of Jerusalem, 1992
  • Medical School: Hebrew University of Jerusalem, 1995
  • Doctorate: Hebrew University of Jerusalem, 2007
  • Member of Editorial Board: Journal of Regenerative Medicine and Tissue Engineering, 2012
  • Travel Award, The Institute of Molecular Imaging Sciences of the Academy of Molecular Imaging, World Molecular Imaging Congress, 2009
  • The Harvey M. Kruger Family Center For Nanoscience and Nanotechnology Prize, Hebrew University of Jerusalem, 2005
  • Finalist, New Investigator Research Award, Orthopedic Research Society, 2004
  • Short-term Research Grant, Minerva Foundation, 2003
  • Travel Award, American Society of Gene Therapy, 2003
  • The Isaac Kaye Innovations Award, Hebrew University of Jerusalem, 2002
  • The Golda Meir Fellow for Excellence, Hebrew University of Jerusalem, 2000
  • Rector's Scholarship for Excellent Graduate Students, Hebrew University of Jerusalem, 2000
  • Biomedical Research Training Scholarship, Israel Ministry of Health, 1999

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Click here for a list of peer-reviewed publications.

  • Shapiro G, Kallai I, Sheyn D, Tawackoli W, Koh YD, Bae H, Trietel T, Goldbart R, Kost J, Gazit Z, Gazit D, Pelled G. Ultrasound-mediated transgene expression in endogenous stem cells recruited to bone injury sites. Polym Adv Technol. 2014;25:525-531.
  • *Ben Arav A, *Pelled G, Zilberman Y, Kimelman-Bleich N, Gazit Z, Schwarz EM, Gazit D. Adeno-associated virus-coated allografts: a novel approach for cranioplasty. J Tissue Eng Regen Med. 2012;6(10):e43-50. (*equal contribution)
  • Pelled G, Snedeker JG, Ben-Arav A, Rigozzi S, Zilberman Y, Kimelman-Bleich N, Gazit Z, Muller R, Gazit D. Smad8/BMP2-engineered mesenchymal stem cells induce accelerated recovery of the biomechanical properties of the Achilles tendon. J Orthop Res. 2012;30(12):1932-1939.
  • Kimelman-Bleich N, Seliktar D, Kallai I, Helm GA, Gazit Z, Gazit D, Pelled G. The effect of ex vivo dynamic loading on the osteogenic differentiation of genetically engineered mesenchymal stem cell model. J Tissue Eng Regen Med. 2011;5(5):384-393.
  • Pelled G, Tai K, Sheyn D, Zilberman Y, Kumbar S, Nair LS, Laurencin CT, Gazit D, Ortiz C. Structural and nanoindentation studies of stem cell-basedtissue-engineered bone. J Biomech. 2007;40(2):399-411.
  • *Hoffmann A, *Pelled G, Turgeman G, Eberle P, Zilberman Y, Shinar H,Keinan-Adamsky K, Winkel A, Shahab S, Navon G, et al. Neotendon formation induced by manipulation of the Smad8 signalling pathway in mesenchymal stem cells. J Clin Invest. 2006;116(4):940-952. (*equal contribution)

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