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Miklos Peterfy, PhD

Associate Professor, Medicine



Research Office:



Miklos Peterfy, PhD

Associate Professor, Medicine

Research in the Peterfy laboratory focuses on genetic determinants of metabolic traits in order to gain mechanistic insights into common metabolic abnormalities such as obesity, diabetes and dyslipidemia. A major emphasis in the laboratory is the role of ER homeostasis in the regulation of plasma triglyceride and cholesterol metabolism in the context of cardiovascular disease.

  • Undergraduate: Budapest University of Technology, Hungary, 1986
  • Doctorate: Budapest University of Technology, Hungary, 1990
  • David L. Rimoin Teaching Excellence Award, 2013
  • Scientific peer-reviewer, American Heart Association, 2008-present
  • Scientific peer-reviewer, National Science Foundation, 2014
  • Reviewer: Physiological Genomics, Current

Click here for a list of peer-reviewed publications.

  • Ben-Zeev, O., Hosseini, M., Lai, C., Ehrhardt, N., Cefalu, A. B., Noto, D., Averna, M. R., Doolittle, M. H., Peterfy, M. Lipase maturation factor 1 is required for endothelial lipase activity. J Lipid Res. 2011;52: 1162-1169. http://www.jlr.org/content/52/6/1162.long
  • Davis, R. C., Castellani, L. W., Hosseini, M., Ben-Zeev, O., Mao, H. Z., Weinstein, M. M., Jung, D. Y., Jun, J. Y., Kim, J. K., Lusis, A. J., Peterfy, M. Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice. Diabetes. 2010;59:1616-1625. http://diabetes.diabetesjournals.org/content/59/7/1616.long
  • Doolittle, M. H., Neher, S. B., Ben-Zeev, O., Ling-liao, J., Gallagher, C. M., Hosseini, M., Yin, F., Wong, H., Walter, P., Peterfy, M. Lipase Maturation Factor 1, Membrane topology and interaction with lipase proteins in the endoplasmic reticulum. J Biol Chem. 2009;284: 33623-33633. http://www.jbc.org/content/284/48/33623.long
  • Hosseini, M., Ehrhardt, N., Weissglas-Volkov, D., Lai, C-M., Mao, H. Z.., Liao, J., Nikkola E., Bensadoun, A., E., Taskinen, M-R., Doolittle, M. H., Pajukanta, P., Peterfy, M. Transgenic expression and variation of LMF1 affect LPL activity in mice and humans. Arterioscler. Thromb Vasc Biol. 2012;32: 1204-1210. http://atvb.ahajournals.org/content/32/5/1204.long
  • Sha, H., Francisco, A., Ehrhardt, N., Sun, S., Xue, Z., Liu, L., Guber, R., Panhwar, M. S., Hang, S., Xue, B., Brenna, J. T., Kersten, S., Bensadoun, A., Peterfy, M.*, et al. The ER-Associated degradation adapter protein Sel1L regulates triglyceride metabolism via lipoprotein lipase. Cell Metab. 2014;20: 458-470. http://www.sciencedirect.com/science/article/pii/S1550413114003076 *co-senior authors
  • Peterfy, M., Ben-Zeev, O., Mao, H. Z., Weissglas-Volkov, D., Aouizerat, B. E., Pullinger, C. R., Frost, P.H., Kane, J. P., Malloy, M. J., Reue, K.,et al. Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia. Nat Genet. 2007;39(12): 1483-1487.

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