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Dhruv Sareen, PhD

Assistant Professor, Biomedical Sciences

Director, Induced Pluripotent Stem Cell Core Facility

Dhruv Sareen, PhD

Assistant Professor, Biomedical Sciences

Director, Induced Pluripotent Stem Cell Core Facility

The research of Dhruv Sareen, PhD, focuses on molecular pathogenesis underlying neuro-developmental and -degenerative diseases, as well as understanding the molecular basis of signals that converge in the brain to impact energy metabolism and homeostasis in obesity. His research employs human induced pluripotent stem cell (iPSC)-based disease-in-a-dish models to understand the neurobiology of spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), neurofibromatosis type 1 (NF1), and obesity. Bio-engineer human stem cell based ex vivo organ models. Sareen developed screening assays to test direct molecular therapeutics by high-content imaging in the iPSC-based cellular models.

  • Editorial Board: The Journal of Rare Disorders, Current
  • Travel Award, International Society for Stem Cell Research, 2012
  • International Society for Stem Cell Research, 2010
  • Wisconsin Entrepreneurial Bootcamp Certificate, University of Washington School of Business, 2009
  • Society for Neuroscience, 2007
  • Harry Karavolas Graduate Student Scholarship, 2002

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  • Ebert AD, Shelley BC, Hurley AM, Onorati M, Castiglioni V, Patitucci TN, Svendsen SP, Mattis VB, McGivern JV, Schwab AJ, Sareen D, et al. EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs. Stem Cell Res. 2013 May;10(3):417-427.
  • Saitta B, Passarini J, Sareen D, Ornelas L, Sahabian A, Argade S, Krakow D, Cohn DH, Svendsen CN, Rimoin DL. Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1. Stem Cells Dev. 2014 Jul 1;23(13):1464-1478.
  • Sareen D, Ebert AD, Heins BM, McGivern JV, Ornelas L, Svendsen CN. Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy. PLoS One. 2012;7(6):e39113.
  • Sareen D, Gowing G, Sahabian A, Staggenborg K, Paradis R, Avalos P, Latter J, Ornelas L, Garcia L, Svendsen CN. Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord. J Comp Neurol. 2014 Aug 15;522(12):2707-2728.
  • Sareen D, O'Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, et al. Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Sci Transl Med. 2013 Oct 23;5(208):208ra149.
  • Sareen D, Svendsen CN. Stem cell biologists sure play a mean pinball. Nat Biotechnol. 2010 Apr;28(4):333-335.

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