Peng Shi, MD, PhD
Peng Shi, MD, PhD
Hypertension is called the silent killer; it is the most common complication in most cardiovascular diseases, such as stroke and heart failure. More than 30 percent of the Western population suffers from this health issue. Unfortunately, the etiology of most cases of hypertension remains uncertain. It is well-appreciated that the central nervous system is essential in regulating blood pressure; renal sympathetic denervation produced significant blood pressure lowering in treatment-resistant hypertensive patients. However, what disturbs the central regulation of blood pressure in hypertension is unclear. The research team of Peng Shi, PhD, is trying to explore the brain mechanism by targeting microglia, the innate resident immune cells, during the development of hypertension. The team's previous work indicates that central anti-inflammation could significantly suppress blood pressure and sympathetic tone in hypertensive animals. To gain deeper understanding of the involvement of microglia, neuroinflammation and associated molecular events in the progress of hypertension, the team is focusing on three aspects: to examine the effects of microglia on sympathetic outflow, neurohumoral release and pathophysiological changes associated with hypertension; to characterize a distinctive molecular signature of microglial activation associated with hypertension; and to understand how microglial activation changes the progress of hypertension and its molecular basis.
- Doctorate: University of Texas Health Science Center at San Antonio, 2007
Awards & Activities
- American Heart Association, 2008
- American Physiological Society, 2006
Click here for a list of peer-reviewed publications.
- Shen XZ, Li Y, Li L, Shah KH, Bernstein KE, Lyden P, Shi P. Microglia participate in neurogenic regulation of hypertension. Hypertension. 2015;66(2):309-316.
- Shi P, Grobe JL, Desland FA, Zhou G, Shen XZ, Shan Z, Liu M, Raizada MK, Sumners C. Direct pro-inflammatory effects of prorenin on microglia. PLoS One. 2014;9(10):e92937.
- de Kloet AD, Krause EG, Shi PD, Zubcevic J, Raizada MK, Sumners C. Neuroimmune communication in hypertension and obesity: a new therapeutic angle?. Pharmacol Ther. 2013;138(3):428-440.
- Jiang N, Shi P, Desland F, Kitchen-Pareja MC, Sumners C. Interleukin-10 inhibits angiotensin II-induced decrease in neuronal potassium current. Am J Physiol Cell Physiol. 2013;304(8):C801-807.
- Shan Z, Zubcevic J, Shi P, Jun JY, Dong Y, MurcaTM, Lamont GJ, Cuadra A, Yuan W, Qi Y, et al. Chronic knockdown of the nucleus of the solitary tract AT1 receptors increases blood inflammatory-endothelial progenitor cell ratio and exacerbates hypertension in the spontaneously hypertensive rat. Hypertension. 2013;61(6):1328-1333.
- Zubcevic J, Jun JY, Lamont G, Murca TM, Shi P, Yuan W, Lin F, Carvajal JM, Li Q, Sumners C, et al. Nucleus of the solitary tract (pro)renin receptor-mediated antihypertensive effect involves nuclear factor-kB-cytokine signaling in the spontaneously hypertensive rat. Hypertension. 2013;61(3):622-627.