Brennan M. Spiegel, MD

Director, Health Services Research in Academic Affairs and Clinical Transformation

8723 W. Alden Drive
Steven Spielberg Building
Los Angeles, CA 90048

Brennan M. Spiegel, MD

Director, Health Services Research in Academic Affairs and Clinical Transformation

  • IM/Gastroenterology

Celiac Disease





Gastroesophageal Reflux (GERD)


Irritable Bowel Syndrome (IBS)

Peptic Ulcers

Stomach Disorders (Nausea, Pain, Vomiting)

Swallowing Disorders (Dysphagia)

Brennan M. Spiegel, MD, is the director of Cedars-Sinai Health Services Research. Spiegel has published numerous medical textbooks, editorials and more than 150 articles in peer-reviewed journals. He an editor-in-chief of the American Journal of Gastroenterology, the leading clinical gastroenterology journal in North America. Spiegel is also director of the Cedars-Sinai Center for Outcomes Research and Education, where he oversees a team that studies how digital health technologies, like wearable biosensors, smartphone applications, and social media, can be used to strengthen the patient-doctor bond, improve outcomes, and save money. Beyond developing digital health innovations, Spiegel’s group conducts psychometric, health-economic, epidemiologic, and qualitative research across a wide range of healthcare topics. As a member of the U.S. Food and Drug Administration Field Advisory Committee, Spiegel is also focused on developing valid and reliable endpoints for clinical trials. His research team receives funding from the National Institutes of Health, Robert Wood Johnson Foundation, U.S. Department of Veterans Affairs and other industry sources.

View NIH Biographical Sketch as a PDF

  • Medical School: New York Medical College, 1998
  • Residency: Cedars-Sinai, 2001
  • Fellowship: David Geffen School of Medicine at UCLA, 2004

View CV as a PDF

  • Elected Co-Editor-in-Chief: American Journal of Gastroenterology, 2015
  • Outstanding Research Paper of 2013, American Society of Gastrointestinal Endoscopy, 2013
  • Appointed as Fellow of the American Gastroenterological Association, 2011
  • Appointed to FDA Gastroenterology Field Advisory Board, 2008
  • Appointed as Fellow of the American College of Gastroenterology, 2008
  • Emerging Leaders in Gastroenterology Award, 2004
  • Veterans Affaris Research Career Development Award, 2004
  • Janssen Research Excellence in Gastroenterology and Liver Award, 2003
  • Leo G Rigler Award for "Resident of the Year", Cedars-Sinai, 1998
  • Alpha Omega Alpha National Honors Society, 1997

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Click here for a list of peer-reviewed publications.

  • Spiegel BM, Hays RD, Bolus R, Melmed GY, Chang L, Whitman C, Khanna PP, Paz SH, Hays T, Reise S, et al. Development of the NIH Patient-Reported Outcomes Measurement Information System (PROMIS) gastrointestinal symptom scales. Am J Gastroenterol. 2014;110(14):608.
  • Spiegel BM, Khanna D, Bolus R, Agarwal N, Khanna P, Chang L. Understanding gastrointestinal distress: a framework for clinical practice. Am J Gastroenterol. 2011;106(3):380-385.
  • Spiegel BM, Kaneshiro M, Russell MM, Lin A, Patel A, Tashjian VC, Zegarski V, Singh D, Cohen SE, Reid MW, et al. Validation of an acoustic gastrointestinal surveillance biosensor for postoperative ileus. J Gastrointest Surg. 2014;18(10):1795-1803.
  • Spiegel BM, DeRosa VP, Gralnek IM, Wang V, Dulai GS. Testing for celiac sprue in diarrhea-predominant irritable bowel syndrome: a cost-effectiveness analysis. Gastroenterology. 2004;126(7):1721-1732.
  • Chan M; Cohen H; Spiegel BM. Colonoscopy yields fewer polyps as the day progresses: Experience in a Veteran Administration teaching hospital. Clin Gastroenterol Hepatol. 2009;7(11):1217-1223.
  • Almario CV, Chey W, Kaung A, Whitman C, Fuller G, Reid M, Nguyen K, Bolus R, Dennis B, Encarnacion R, Martinez B, Talley J, Modi R, Agarwal N, Lee A, Kubomoto S, Sharma G, Bolus S, Chang L, Spiegel BM. Computer-generated vs. physician-documented history of present illness (HPI): results of a blinded comparison. Am J Gastroenterol. 2015;110(1):170-179.

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