Shelly C. Lu, MD

Vice Chair, Basic Science and Translational Research

Director, Division of Gastroenterology

Shelly C. Lu, MD

Vice Chair, Basic Science and Translational Research

Director, Division of Gastroenterology

  • IM/Gastroenterology


Gastrointestinal Disorders

Liver Disorders

Shelly Lu, MD, has been working in the fields of S-adenosylmethionine and glutathione metabolism for more than 20 years and has received uninterrupted funding from the National Institutes of Health (NIH) since 1992. Lu currently has five active NIH-funded research programs that investigate molecular mechanisms of fatty liver, liver injury, liver cancer and colon cancer. Many of the research projects have translational applications, such as identifying biomarkers that can differentiate simple fatty liver from those with more a severe form called nonalcoholic steatohepatitis, identifying biomarkers that might predict prognosis and response to chemotherapy in colon cancer, and examining agents that are effective in the prevention and treatment of liver and colon cancer.

  • Medical School: UCLA School of Medicine, 1982
  • Residency: Cedars-Sinai, 1985
  • Fellowship: UCLA, 1988
  • Editor, Comprehensive Physiology: Liver Physiology, 2011-present
  • Best Attending in Gastroenterology, Los Angeles County+USC Medical Center, 2014
  • Mayo Soley Award – Lifetime Achievement in Science and Mentoring, 2012
  • Associate Editor, Hepatology, 2006-11
  • Outstanding Women in Science, American Gastroenterological Association, 2008
  • Association of American Physicians (Old Turk), 2006
  • Outstanding Investigator Award, Western Society of Clinical Investigation, 2005
  • Associate Editor, American J. Physiol. GI liver Section, 2001-03
  • American Society for Clinical Investigation (Young Turk), 2002
  • Best Attending of the Firm, Los Angeles County+USC Medical Center, 2001

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Click here for a list of peer-reviewed publications.

  • Yang H, Li TW, Zhou Y, Peng H, Liu T, Zandi E, Martínez-Chantar ML, Mato JM, Lu SC. Activation of a novel c-Myc-miR27-prohibitin 1 circuitry in cholestatic liver injury inhibits glutathione synthesis in mice. Antioxid Redox Signal. 2015;22:259-274.

English / Chinese (Mandarin) / English

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