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Simon Knott, PhD

Assistant Professor, Biomedical Sciences

Associate Director, Center for Bioinformatics and Functional Genomics

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Simon Knott, PhD

Assistant Professor, Biomedical Sciences

Associate Director, Center for Bioinformatics and Functional Genomics

Simon Knott, PhD, combines computational biology and functional genomics to elucidate the molecular mechanisms that drive cancer progression. Work in his laboratory is focused on three main areas: heterogeneity in cancer cell populations and how it impacts disease outcome, hetero-cellular interactions that allow cancer cells to manipulate the tumor microenvironment to evade therapy, and the development of novel computational and molecular tools to study disease progression.

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  • Doctorate: University of Southern California, 2011
  • Post Doctorate: Cold Spring Harbor Laboratory, 2016

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  • Winnick Scholar, 2017-current
  • Hope Funds for Cancer Research Postdoctoral Fellow Fellowship, 2012-15
  • Harrison Kutz Award for the most outstanding PhD in Biological Sciences. University of Southern California, 2011

Click here for a list of peer-reviewed publications.

  • Erard N, Knott SRV, Hannon GJ. A CRISPR resource for individual, combinatorial, or multiplexed gene knockout. Mol Cell. 2017 Jul 20;67(2):348-354.e3.
  • Wagenblast E, Soto M, Gutiérrez-Ángel S, Hartl CA, Gable AL, Maceli AR, Erard N, Williams AM, Kim SY, Dickopf S, Harrell CJ, Smith AD, Perou CM, Wilkinson JE, Hannon GJ, Knott SRV. A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis. Nature. 2015;520(7547):358-362.
  • Knott SRV, Maceli A, Erard N, Chang K, Marran K, Zhou X, Gordon A, El Demerdash O, Wagenblast E, Kim S, et al. A computational algorithm to predict shRNA potency. Mol Cell. 2014;56(6):796-807.
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