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Philip K. Frykman, MD, PhD, FAAP, FACS, MBA

Associate Director, Division of General Pediatric Surgery

Steven Spielberg Building
8723 Alden Drive
Suite 240
Los Angeles, CA 90048





Parking Instructions:

Parking is available in Lot 2. Validation will be provided.

Philip K. Frykman, MD, PhD, FAAP, FACS, MBA

Associate Director, Division of General Pediatric Surgery

  • Pediatric Surgery

Branchial Cleft Cysts

Choledochal Cysts

Colorectal Surgery / Surgeries (Colon, Rectal)

Congenital Diaphragmatic Hernias

Crohn's Disease - Pediatric

Esophageal Disorders - Pediatric

Gastroesophageal Reflux (GERD)

Gastrointestinal Disorders - Pediatric

Hernias - Pediatric

Imperforate Anus Repair

Inflammatory Bowel Disease (IBD) - Pediatric

Nissen Fundoplication

Pectus Excavatum Repairs (Chest Wall Deformity)

Splenectomy (Spleen Removal)

Stomach Disorders (Nausea, Pain, Vomiting) - Pediatric

Thyroglossal Duct Cysts

Ulcerative Colitis - Pediatric

Video-Assisted Thoracoscopic Surgery / Surgeries (VATS) - Pediatric

The research of Philip Frykman, MD, PhD, focuses on identifying the genetic, immune and microbial mechanisms leading to complications in children with Hirschsprung disease. The most frequent and serious complication is Hirschsprung-associated enterocolitis (HAEC). His research team developed a surgical mouse model of post-pull-through HAEC, extensively characterizing the enterocolitis in the Ednrb-null mouse, thereby establishing a valuable animal model of HAEC that closely mimics that of children with Hirschsprung disease. The Frykman Laboratory is studying how immune cell trafficking and function may influence development of HAEC. Additionally, the lab is exploring the changes in gut bacteria and fungi populations in children who develop HAEC compared with those who do not develop the disease.

  • Medical School: University of Texas Southwestern Medical Center, 1997
  • Doctorate: University of Texas Southwestern Graduate School of Biomedical Sciences, 1997
  • Residency: University of Cincinnati Medical Center, 2002
  • Residency: Children's Hospital of Alabama, 2004
  • Editorial Consultant for European Journal of Pediatric Surgery, Current
  • Reviewer: Journal of Pediatric Surgery, Current
  • Reviewer: Journal of Pediatrics, Current
  • Hope Award, Mending Kids International, 2014
  • K08 Career Development Award, National Institutes of Health, 2011
  • Fellow, American College of Surgeons, 2007
  • Fellow, American Academy of Pediatrics, 2008
  • International Pediatric Endosurgery Group, 2004
  • Alpha Omega Alpha, 2001
  • Medical Scientist Training Program Fellowship, 1990

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Click here for a list of peer-reviewed publications.

  • Frykman PK, Cheng Z, Wang X, Dhall D. Enterocolitis causes profound lymphoid depletion in endothelin receptor B- and endothelin 3-null mouse models of Hirschsprung-associated enterocolitis. Eur J Immunol. 2015;45(3):807-817.
  • Cheng Z, Wang X, Dhall D, Zhao L, Bresee C, Doherty TM, Frykman PK. Splenic lymphopenia in the endothelin receptor B-null mouse: implications for Hirschsprung associated enterocolitis. Pediatr Surg Int. 2011;27(2):145-140.
  • Frykman PK, Short SS. Hirschsprung-Associated Enterocolitis: Prevention and Therapy. Semin Pediatr Surg. 2012;21(4):328-335.
  • Short S, Kimble K, Zhai S, Frykman G, Frykman P. A low-cost improvised nerve stimulator is equivalent to high-cost muscle stimulator for anorectal malformation surgery. Eur J Pediatr Surg. 2013;23(1);25-28.
  • Cheng Z, Dhall D, Zhao L, Wang HL, Doherty TM, Bresee C, Frykman PK. Murine model of Hirschsprung-associated enterocolitis. I: phenotypic characterization with development of a histopathologic grading system. J Pediatr Surg. 2010;45(3):475-482.
  • Zhao L, Dhall D, Cheng Z, Wang H., Doherty TM, Bresee C, Frykman PK. Murine model of Hirschsprung-associated enterocolitis II: Surgical correction of aganglionosis does not eliminate enterocolitis. J Pediatr Surg. 2010;45(1).

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