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Philip K. Frykman, MD, PhD, FAAP, FACS, MBA

Associate Director, Division of General Pediatric Surgery

8723 Alden Drive
Steven Spielberg Building, Suite 240
Los Angeles, CA 90048

Phone:

310-423-2331

Fax:

310-423-5454

Parking Instructions:

Parking is available in Lot 2.

Philip K. Frykman, MD, PhD, FAAP, FACS, MBA

Associate Director, Division of General Pediatric Surgery

  • Pediatric Surgery

Branchial Cleft Cysts

Choledochal Cysts

Colorectal Surgery / Surgeries (Colon, Rectal)

Congenital Diaphragmatic Hernias

Crohn's Disease - Pediatric

Esophageal Disorders - Pediatric

Gastroesophageal Reflux (GERD)

Gastrointestinal Disorders - Pediatric

Hernias - Pediatric

Imperforate Anus Repair

Inflammatory Bowel Disease (IBD) - Pediatric

Nissen Fundoplication

Pectus Excavatum Repairs (Chest Wall Deformity)

Splenectomy (Spleen Removal)

Stomach Disorders (Nausea, Pain, Vomiting) - Pediatric

Thyroglossal Duct Cysts

Ulcerative Colitis - Pediatric

Video-Assisted Thoracoscopic Surgery / Surgeries (VATS) - Pediatric

The research of Philip K. Frykman, MD, PhD, MBA, FAAP, FACS, focuses on basic mechanisms of Hirschsprung disease (HSCR). As a pediatric surgeon-scientist, Frykman has been particularly focused on investigating the biological mechanisms underpinning why some children with HSCR develop severe, life-threatening enterocolitis (HAEC) while others didn't. Through his decadelong studies, his lab has made important contributions by developing robust animal models of HAEC, creating and validating a murine histopathological enterocolitis scoring system to study the foundational biology of HAEC. His lab has delineated the immunobiology of the immune disorder in HAEC, showing that the lymphopenia is not a result of endothelin and receptor signaling deficit, but rather is secondary to endocrine physiologic and gut microbial alterations caused by intestinal stasis. Currently, Frykman is focused on characterizing the intestinal bacterial and fungal microbiota of children with HSCR, with particular interest in defining the differences in those who developed HAEC. In collaboration with David Underhill, PhD, Frykman is investigating the roles of fungi and antifungal innate immunity in development HAEC, as this could directly impact the diagnosis and treatment of children with HAEC.

  • Medical School: University of Texas Southwestern Medical Center, 1997
  • Doctorate: University of Texas Southwestern Graduate School of Biomedical Sciences, 1997
  • Residency: University of Cincinnati Medical Center, 2002
  • Residency: Children's of Alabama, 2004
  • Editorial Consultant: European Journal of Pediatric Surgery, Current
  • Reviewer: Journal of Pediatric Surgery, Current
  • Reviewer: Journal of Pediatrics, Current
  • Hope Award, Mending Kids International, 2014
  • K08 Career Development Award, National Institutes of Health, 2011
  • Fellow, American Academy of Pediatrics, 2008
  • Fellow, American College of Surgeons, 2007
  • International Pediatric Endosurgery Group, 2004
  • Alpha Omega Alpha, 2001
  • Medical Scientist Training Program Fellowship, 1990

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Click here for a list of peer-reviewed publications.

  • Frykman PK, Nordenskjold A, Kawaguchi A, Hui TT, Granstrom AL, Cheng Z, Tang J, Underhill DM, Iliev I, Funari VA, et al. Characterization of bacterial and fungal microbiome in children with Hirschsprung disease with and without a history of enterocolitis: a multicenter study. PLoS One. 2015;10(4):e0124172.
  • Frykman PK, Cheng Z, Wang X, Dhall D. Enterocolitis causes profound lymphoid depletion in endothelin receptor B- and endothelin 3-null mouse models of Hirschsprung-associated enterocolitis. Eur J Immunol. 2015;45(3):807-817.
  • Short S, Kimble K, Zhai S, Frykman G, Frykman P. A low-cost improvised nerve stimulator is equivalent to high-cost muscle stimulator for anorectal malformation surgery. Eur J Pediatr Surg. 2013;23(1);25-28.
  • Frykman PK, Short SS. Hirschsprung-associated enterocolitis: prevention and therapy. Semin Pediatr Surg. 2012;21(4):328-335.
  • Cheng Z, Wang X, Dhall D, Zhao L, Bresee C, Doherty TM, Frykman PK. Splenic lymphopenia in the endothelin receptor B-null mouse: implications for Hirschsprung associated enterocolitis. Pediatr Surg Int. 2011;27(2):145-140.
  • Cheng Z, Dhall D, Zhao L, Wang HL, Doherty TM, Bresee C, Frykman PK. Murine model of Hirschsprung-associated enterocolitis. I: phenotypic characterization with development of a histopathologic grading system. J Pediatr Surg. 2010;45(3):475-482.

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