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Mark O. Goodarzi, MD, PhD

Eris M. Field Chair in Diabetes Research

Director, Endocrinology, Diabetes & Metabolism

Director, Endocrine Genetics Laboratory

Professor, Medicine

8723 Alden Drive
Steven Spielberg Building
Suite 250
Los Angeles, CA 90048

Phone:

310-423-3870

Fax:

310-423-0429

Mark O. Goodarzi, MD, PhD

Eris M. Field Chair in Diabetes Research

Director, Endocrinology, Diabetes & Metabolism

Director, Endocrine Genetics Laboratory

Professor, Medicine

  • IM/Endocrinology

Addison's Disease

Adrenal Gland Disorders

Calcium Disorders

Diabetes Mellitus (Type 1 & 2)

Hypoglycemia

Insulin Resistance

Osteopenia (Low Bone Density)

PCOS (Polycystic Ovary Syndrome)

Parathyroid Disorders

Pituitary Disorders

Prediabetes

Thyroid Disorders

The lab of Mark Goodarzi, MD, PhD, seeks to identify genetic factors underlying conditions related to insulin resistance and the metabolic syndrome, using a population genetic approach. A major focus area is elucidation of the genetic determinants of insulin clearance, via candidate gene and genome-wide association analyses. Other areas of interest include insulin resistance and atherosclerosis in Hispanics and the polycystic ovary syndrome. Pharmacogenetic studies are focused on the glycemic response to statins. Another research effort is an NIH-funded study examining the ability of GLP-1 agonists to prevent diabetes in Hispanic women with prediabetes, where insulin-related traits are measured by detailed physiologic phenotyping techniques. As the co-convener of the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Glycemia-Diabetes Working Group, Dr. Goodarzi also leads an international consortium that assembled over 20 cohorts (comprising over 100,000 individuals) for the study of common and rare variants that contribute to glucose homeostasis and type 2 diabetes. Dr. Goodarzi also leads the Type 3c Diabetes Working Group within the U01-funded Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC), where he seeks to elucidate the pathophysiology of pancreatogenic diabetes using genetic and physiologic approaches. Dr. Goodarzi also leads the Microbiome and Insulin Longitudinal Evaluation Study (MILES), which is the first prospective study examining the effect of the gut microbiome and diet on insulin resistance, insulin sensitivity, and insulin clearance, to establish the causal role of gut microbes in the development of diabetes.

View NIH Biographical Sketch as a PDF

  • Undergraduate: Harvard University, 1993
  • Medical School: University of California, San Franscisco, 1997
  • Residency: UCLA Medical Centerr, 1999
  • Fellowship: UCLA Medical Center, 2004
  • Doctorate: UCLA, 2004
  • Fellowship in the American College of Physicians, 2015
  • Golden Tiger Award for Working Group Leadership, CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium, 2014
  • Endocrine Society Richard E. Weitzman Memorial Award, 2010
  • Outstanding Investigator Award, Western Section, American Federation for Medical Research, 2008
  • Young Investigator Award, Androgen Excess Society, 2006, 2007

Click here for a list of peer-reviewed publications.

  • Goodarzi MO, Taylor KD, Guo X, Quinones MJ, Cui J, Li X, Hang T, Yang H, Holmes E, Hsueh WA, et al. Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait. Diabetes. 2005 Apr;54(4):1222-1227.
  • Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YD, Taylor KD, Buchanan TA, Davis RC, Hsueh WA, Raffel LJ, Rotter JI, Goodarzi MO. Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis. Diabetologia. 2012 Aug;55(8):2183-2192.
  • Goodarzi MO, Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YDI, Taylor KD, Buchanan TA, Hsueh WA, et al. Systematic evaluation of validated type 2 diabetes and glycemic trait loci for association with insulin clearance. Diabetologia. 2013 Jun;56(6):1282-1290.
  • Brower MA, Jones MR, Rotter JI, Krauss RM, Legro RS, Azziz R, Goodarzi MO. Further investigation in Europeans of susceptibility variants for polycystic ovary syndrome discovered in genome-wide association studies of Chinese individuals. J Clin Endocrinol Metab. 2015 Jan;100(1):E182-186.
  • Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert MF, Raghavan S, Lipovich L, Hidalgo B, Fox K, Huffman JE, An P, Lu Y, Rasmussen-Torvik LJ, Grarup N, Ehm MG, Li L, Baldridge AS, Stančáková A, Abrol R, Besse C, Boland A, Bork-Jensen J, Fornage M, Freitag DF, Garcia ME, Guo X, Hara K, Isaacs A, Jakobsdottir J, Lange LA, Layton JC, Li M, Hua Zhao J, Meidtner K, Morrison AC, Nalls MA, Peters MJ, Sabater-Lleal M, Schurmann C, Silveira A, Smith AV, Southam L, Stoiber MH, Strawbridge RJ, Taylor KD, Varga TV, Allin KH, Amin N, Aponte JL, Aung T, Barbieri C, Bihlmeyer NA, Boehnke M, Bombieri C, Bowden DW, Burns SM, Chen Y, Chen YD, Cheng CY, Correa A, Czajkowski J, Dehghan A, Ehret GB, Eiriksdottir G, Escher SA, Farmaki AE, Frånberg M, Gambaro G, Giulianini F, Goddard WA 3rd, Goel A, Gottesman O, Grove ML, Gustafsson S, Hai Y, Hallmans G, Heo J, Hoffmann P, Ikram MK, Jensen RA, Jørgensen ME, Jørgensen T, Karaleftheri M, Khor CC, Kirkpatrick A, Kraja AT, Kuusisto J, Lange EM, Lee IT, Lee WJ, Leong A, Liao J, Liu C, Liu Y, Lindgren CM, Linneberg A, Malerba G, Mamakou V, Marouli E, Maruthur NM, Matchan A, McKean-Cowdin R, McLeod O, Metcalf GA, Mohlke KL, Muzny DM, Ntalla I, Palmer ND, Pasko D, Peter A, Rayner NW, Renström F, Rice K, Sala CF, Sennblad B, Serafetinidis I, Smith JA, Soranzo N, Speliotes EK, Stahl EA, Stirrups K, Tentolouris N, Thanopoulou A, Torres M, Traglia M, Tsafantakis E, Javad S, Yanek LR, Zengini E, Becker DM, Bis JC, Brown JB, Cupples LA, Hansen T, Ingelsson E, Karter AJ, Lorenzo C, Mathias RA, Norris JM, Peloso GM, Sheu WH, Toniolo D, Vaidya D, Varma R, Wagenknecht LE, Boeing H, Bottinger EP, Dedoussis G, Deloukas P, Ferrannini E, Franco OH, Franks PW, Gibbs RA, Gudnason V, Hamsten A, Harris TB, Hattersley AT, Hayward C, Hofman A, Jansson JH, Langenberg C, Launer LJ, Levy D, Oostra BA, O'Donnell CJ, O'Rahilly S, Padmanabhan S, Pankow JS, Polasek O, Province MA, Rich SS, Ridker PM, Rudan I, Schulze MB, Smith BH, Uitterlinden AG, Walker M, Watkins H, Wong TY, Zeggini E; EPIC-InterAct Consortium, Laakso M, Borecki IB, Chasman DI, Pedersen O, Psaty BM, Tai ES, van Duijn CM, Wareham NJ, Waterworth DM, Boerwinkle E, Kao WH, Florez JC, Loos RJ, Wilson JG, Frayling TM, Siscovick DS, Dupuis J, Rotter JI, Meigs JB, Scott RA, Goodarzi MO. Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nat Commun. 2015 Jan 29;6:5897
  • Goodarzi MO. Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications. Lancet Diabetes Endocrinol. 2018;6:223-236

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