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Mark O. Goodarzi, MD, PhD

Director, Endocrinology, Diabetes & Metabolism

Director, Endocrine Genetics Laboratory

Professor, Medicine

Steven Spielberg Building
8723 Alden Drive, Suite 250
Los Angeles, CA 90048

Phone:

310-423-3870

Fax:

310-423-0429

Parking Instructions:

http://www.cedars-sinai.edu/Patients/Patient-and-Visitor-Resources/Getting-Here/Parking.aspx

Mark O. Goodarzi, MD, PhD

Director, Endocrinology, Diabetes & Metabolism

Director, Endocrine Genetics Laboratory

Professor, Medicine

  • IM/Endocrinology

Addison's Disease

Adrenal Gland Disorders

Calcium Disorders

Diabetes Mellitus (Type 1 & 2)

Hypoglycemia

Insulin Resistance

Osteopenia (Low Bone Density)

Osteoporosis

PCOS (Polycystic Ovary Syndrome)

Parathyroid Disorders

Pituitary Disorders

Prediabetes

Thyroid Disorders

ENDOCRINE GENETICS LABORATORY: The laboratory seeks to identify genetic factors underlying conditions related to insulin resistance and the metabolic syndrome, using a population genetic approach. A major focus area is elucidation of the genetic determinants of insulin clearance, via candidate gene and genome-wide association analyses. Other areas of interest include insulin resistance and atherosclerosis in Hispanics and the polycystic ovary syndrome. Epigenetic contributions to polycystic ovary syndrome are being explored via the study of DNA methylation of tissues isolated from prenatally androgenized animal models. Pharmacogenetic studies are focused on the glycemic response to statins. Another research effort is the phenotyping of insulin resistance by physiologic infusion studies.

View NIH Biographical Sketch as a PDF

  • Undergraduate: Harvard University, 1993
  • Medical School: University of California, San Franscisco, 1997
  • Residency: UCLA Medical Center, Los Angeles, CA, 1999
  • Fellowship: UCLA Medical Center, Los Angeles, CA, 2004
  • Doctorate: University Of California Los Angeles, 2004
  • Young Investigator Award, Androgen Excess Society, 2006, 2007
  • Outstanding Investigator Award, Western Section, American Federation for Medical Research, 2008
  • Endocrine Society Richard E. Weitzman Memorial Award, 2010
  • Golden Tiger Award for Working Group Leadership, CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium, 2014
  • Fellowship in the American College of Physicians (ACP), 2015

Click here for a list of peer-reviewed publications.

  • Goodarzi MO, Taylor KD, Guo X, Quinones MJ, Cui J, Li X, Hang T, Yang H, Holmes E, Hsueh WA, Olefsky J, Rotter JI: Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait. Diabetes, 54(4): 1222-7, 2005
  • Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YD, Taylor KD, Buchanan TA, Davis RC, Hsueh WA, Raffel LJ, Rotter JI, Goodarzi MO. Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis. Diabetologia, 55(8):2183-92, 2012
  • Goodarzi MO, Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YDI, Taylor KD, Buchanan TA, Hsueh WA, Raffel LJ, Rotter JI. Systematic evaluation of validated type 2 diabetes and glycemic trait loci for association with insulin clearance. Diabetologia, 56(6):1282-90, 2013
  • Goodarzi MO, Jones MR, Li X, Chua A, Garcia O, Chen YDI, Krauss RM, Rotter JI, Ankener W, Legro RS, Azziz R, Strauss JF, Dunaif A, Urbanek M. Replication of Association of DENND1A and THADA Variants with polycystic ovary syndrome in European cohorts. J Med Genet, 49(2): 90-5, 2012
  • Brower MA, Jones MR, Rotter JI, Krauss RM, Legro RS, Azziz R, Goodarzi MO. Further investigation in Europeans of susceptibility variants for polycystic ovary syndrome discovered in genome-wide association studies of Chinese individuals. J Clin Endocrinol Metab, 100(1): E182-6, 2015
  • Wessel J, Chu AY, Willems SM, Wang S, et al., Rotter JI, Meigs JB, Scott RA, Goodarzi MO. Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nat Commun, 6:5897, 2015

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