Ali Khoynezhad, MD, FACS

Director, Thoracic Aortic Surgery Program

Advanced Health Sciences Pavilion, Suite A3606
127 S. San Vicente Blvd.
Los Angeles, CA 90048





Ali Khoynezhad, MD, FACS

Director, Thoracic Aortic Surgery Program

  • Surgery-Cardio-Thoracic

Abdominal Aortic Aneurysms

Aortic Aneurysms

Aortic Dissections

Aortic Regurgitation

Aortic Stenosis

Aortic Valve Surgery / Surgeries

Aortic Valve-Sparing Surgery / Surgeries

Arrhythmias (Irregular Heartbeat, Heart Rhythm Disorders)

Atrial Fibrillation

Connective Tissue Diseases

Coronary Artery Bypass Surgery / Surgeries (CABG)


Heart Valve Surgery / Surgeries

Marfan's Syndrome


Pulmonary Embolisms

Radiofrequency Ablation

Thoracic Aortic Aneurysms

Tricuspid Valve Surgery


The research of Ali Khoynezhad, MD, focuses on spinal cord ischemia resulting in paraplegia that may be attenuated using novel anti-inflammatory medication such as NMDA-receptor blockers, adjuncts such as ischemic pre- and post-conditioning, and novel stem cell therapeutics. The effectiveness of these promising agents are tested validated in animal model, effective dose-response is established, prior to first-in-human experiments. His other project entails transcatheter aortic valve replacement in mechanical aortic valve prosthesis. Khoynezhad is a leader in outcome research of patients undegoing open and endovascular procedures for aortic dissection. In addition, he developed a classification for endovascular repair of acute type B dissection predicting false lumen-patency in mid- and long-term follow-up. His current research focus is modulating ischemic response of spinal cord, developing in vitro model of acute type A dissection, endovascular repair of aortic root and ascending aorta, as well as transcatheter valve replacement in patients with mechanical aortic valve. He is working on a microsurgical approach to intracardiac operation using transfemoral access and minimally invasive endoluminal cardotid-subclavian bypass and transcatheter aortic valve replacement in mechanical aortic valve prosthesis.

View NIH Biographical Sketch as a PDF

  • Medical School: University of Cologne College of Medicine, 1996
  • Internship: Wake Forest University Baptist Medical Center, 1999
  • Residency: North Shore University Hospital, 2003
  • Fellowship: Montefiore Medical Center, 2005
  • Fellowship: Harbor-UCLA Medical Center, 2005

View CV as a PDF

  • American Association for Thoracic Surgery Member, Annual Meeting Video CommitteeMember, Publication Committee Member, Scientific Affairs & Government Relations Chair, Web Editorial Board Chair, Technology Committee, 2010 - 2015
  • Thoracic Surgery Foundation Research & Education Leadership Scholarship at Brandeis University, 2014
  • 21st Century Cardiothoracic Surgical Society, 2014
  • Society for University Surgeons, 2014
  • Section Editor, Operative Techniques in Thoracic and Cardiovascular Surgery, 2013
  • Editor, The Cardiothoracic Surgery Network, Endovascular Portal., 2006 - 2013
  • American College of Surgeons German Traveling Fellowship Award, 2011
  • University of Nebraska Medical Center Research Innovation Award, 2008
  • American College of Chest Physicians Poster of Distinction Award, 2002
  • American College of Surgeons Murray Friedman Award, 2002

Show moreShow less

Click here for a list of peer-reviewed publications.

  • Khoynezhad A, Jalali Z, Tortolani AJ. Apoptosis: pathophysiology and therapeutic implications for the cardiovascular surgeon. Ann Thorac Surg. 2004;78(3):1109-1118.
  • Khoynezhad A, Bello R, Smego DR, Nwakanma L, Plestis KA. Improved outcome after repair of descending and thoracoabdominal aortic aneurysms using modern adjuncts. Interact Cardiovasc Thorac Surg. 2005;4(6):574-576.
  • Khoynezhad A, Donayre CE, White RA. Techniques and results of endovascular management of acute complicated type B aortic dissection in North America. Rev Cardiovasc Med. 2012;13(4):e176-184.
  • Brecht R, Friedrich M, Heinisch PP, Plonien K, Akra B, Hagl C, Khoynezhad A, Lutter G, Bombien R. Transcatheter valve replacement: new concepts for microsurgery inside the heart. Innovation (Phila). 2013;8(1):29-36.
  • Swerdlow CD, Kass RM, Khoynezhad A. Inside-out insulation failure of a defibrillator lead with abrasion-resistant coating. Heart Rhythm. 2013;10(6):e73.
  • Khoynezhad A, Donayre C, Azizzadeh A, White R. One-year results of the RESCUE trial: TEVAR for traumatic aortic injury remains a favorable therapeutic approach at midterm follow-up. J Thorac Cardiovasc Surg. 2015;149(1):155-161.

Show moreShow less

English / German / Persian / Spanish

Make an Appointment




Available 24 Hours A Day


Many of the physicians who have medical staff privileges to practice medicine at Cedars-Sinai Medical Center are independent physicians, and not employees or agents of the hospital. These independent physicians bill separately for their services. You should contact your physician to determine their status and billing practices.

Send Email to Ali Khoynezhad, MD, FACS