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Ronald B. Natale, MD

Medical Director, Clinical Lung Cancer Program

Cedars-Sinai Medical Center
8700 Beverly Blvd.
Saperstein Critical Care Tower, Suite MS-33
Los Angeles, CA 90048





Parking Instructions:

Parking is available in the Samuel Oschin Cancer Center lot.

Ronald B. Natale, MD

Medical Director, Clinical Lung Cancer Program

  • IM/Hematology/Oncology

Lung Cancers

Prostate Cancers


The major area of interest for Ronald Natale, MD, is in translational clinical trials (phase I-III) with investigational agents in patients with lung cancer. He has more than 30 years of experience with clinical trials and with their continuous evolution over that time period driven by advances in molecular biology and technology. His experiences began with rationally designed empiric trials in the 1980s and 1990s that resulted in his development or co-development of some of the most widely used treatment regimens for lung cancer, including cisplatin and etoposide for small-cell lung cancer (with Robert Wittes, MD, at Memorial Sloan-Kettering Cancer Center) and carboplatin and paclitaxel for non-small-cell lung cancer. During that time, Natale also co-developed the MVAC regimen for bladder cancer (with Alan Yagoda, MD, at Memorial Sloan-Kettering) and went on to serve as the principal coordinator of the Southwest Oncology Group and the national high-priority neoadjuvant MVAC trial in patients with locally advanced bladder cancer (American Society of Clinical Oncology plenary presentation, 2001; New England Journal of Medicine publication, 2003). In 2001, Natale was one of the first investigators involved in the clinical development of the breakthrough EGFR tyrosine kinase inhibitor, gefitinib. He served as co-principal investigator of the registrational trial and was selected to present results before the U.S. Food and Drug Administration's Oncologic Drug Advisory Committee in 2003, during the meeting at which gefitinib was first approved. He has been continuously involved in clinical trials of new targeted agents in lung cancer since that time, with almost all current studies requiring tumor tissue for laboratory translational studies. Natale is now developing new technologies that will quantitate and image the major mechanism of targeted treatment cancer cell death, namely apoptosis, within the first week of the start of treatment.

View NIH Biographical Sketch as a PDF

  • Medical School: Wayne State University, 1974
  • Internship: Hutzel Hospital, 1975
  • Residency: Hutzel Hospital, 1977
  • Fellowship: Memorial Sloan Kettering, 1980
  • Fellowship: National Cancer Insitute, 1988

View CV as a PDF

English / Italian

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