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Margareta D. Pisarska, MD

Associate Professor, Obstetrics and Gynecology

Director, Division of Reproductive Endocrinology and Infertility

Mark Goodson Building
444 S. San Vicente Blvd, Suite 1002
Los Angeles, CA 90048





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Margareta D. Pisarska, MD

Associate Professor, Obstetrics and Gynecology

Director, Division of Reproductive Endocrinology and Infertility

  • OB/GYN-Reproductive Endocrinology
  • Obstetrics & Gynecology

Egg Donor Program (Oocyte)

Fertility Preservation

Hysteroscopic Surgery / Surgeries (Hysteroscopy)

In Vitro Fertilization (IVF)

Infertility (Fertility Disorders) - Female

Infertility (Fertility Disorders) - Male

Intracytoplasmic Sperm Injections

Intrauterine Insemination

Ovulation Induction

Sperm Banking

We are investigating the role of differences in the genetics and epigenetics of pregnancies conceived from couples with infertility, including those conceived through in vitro fertilization. We are also investigating the role of alterations in implantation and their role on adverse pregnancy outcomes. We are able to look at how transcriptional regulation is affected by genetics and epigenetics during early implantation in ongoing pregnancies in order to better understand how these changes lead to adverse pregnancy outcomes. Another area of investigation in our laboratory involves transcriptional regulation in the ovary. We are looking at how certain transcription factors regulate follicle/egg development and premature loss leading to subsequent infertility. Specifically, we are investigating the role of FOXL2, a transcription factor associated with premature ovarian failure.

  • Medical School: Upstate Medical Center N.Y., 1992
  • Residency: Lenox Hill Hospital, 1996
  • Division Member, American Board of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility Division, 2011-2017
  • Chairperson, Patient Education Committee, American Society for Reproductive Medicine, 2012 - Present
  • Patient Education Committee, American Society for Reproductive Medicine, 2012 - Present
  • Reviewer, Integrative and Clinical Endocrinology and Reproduction Study Section, National Institute of Health, 2009 -2012
  • Ad-Hoc Reviewer, National Institutes of Health, 2007-present
  • Best Doctors in America 2007-Present, 2007-present
  • Southern California Super Doctors, 2011-2014
  • Office of Research on Women's Health (ORWH) REAP Award, 2006
  • Society for Reproductive Investigation, 2005-present
  • Society of Reproductive Endocrinology and Infertility, 1996-present

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  • Jackson S, Hong C, Wang ET, Alexander C, Gregory KD, Pisarska MD. Pregnancy outcomes in very advanced maternal age pregnancies: the impact of assisted reproductive technology. Fertil Steril. 2015 Jan; 103(1):76-80. Epub 2014 Oct 25. PMID: 25450294
  • Conway D, Patel S, Liem J, Fan K, Jalian J, Williams III J, Pisarska MD. The Risk of Cytogenetic Abnormalities in the Late First Trimester in Pregnancies Conceived Through Assisted Reproduction Fertil Steril 2011. Feb; 95 (2) 503-6 PMID: 20947075
  • Kuo FT, Fan K, Bentsi-Barnes I, Barlow GM, Pisarska MD. Mouse Forkhead L2 (FOXL2) maintains repression of FSH-dependent genes in the granulosa cell. Reproduction 2012 Oct;144(4):485-494 PMID: 22847492
  • Kuo F, Fan K, Bentsi-Barnes I, Barlow G, Pisarska MD. Mutant Forkhead L2 (FOXL2) proteins associated with Premature Ovarian Failure (POF) likely Dimerize with wild type FOXL2, leading to altered regulation of Genes associated with Granulosa Cell Differentiation. Endocrinology. 2011 Oct:152(10):3917-29, 2011 PMC 3176639 PMID: 21862621
  • Pisarska MD, Bae J, Klein C, Hsueh AJ: Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene. Endocrinology, 145(7): 3424-33, 2004
  • Kawamura K, Kumagai J, Sudo S, Chun SY, Pisarska M, Morita H, Toppari J, Fu P, Wade JD, Bathgate RA, Hsueh AJ: Paracrine regulation of mammalian oocyte maturation and male germ cell survival. Proc. Natl. Acad. Sci. U.S.A., 101(19): 7323-8, 2004

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