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Kenneth Bernstein, MD

Director, Experimental Pathology in the Department of Academic Pathology

Director, Research Education Programs in the Division of Immunology Research

Professor, Pathology and Lab Medicine

Professor, Biomedical Sciences

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310-423-3527

Kenneth Bernstein, MD

Director, Experimental Pathology in the Department of Academic Pathology

Director, Research Education Programs in the Division of Immunology Research

Professor, Pathology and Lab Medicine

Professor, Biomedical Sciences

The Bernstein laboratory studies the renin-angiotensin system, a collection of proteins important in blood pressure control, heart disease and renal disease. Genetic models in mice are used to investigate the basic physiology and biochemistry of the renin-angiotensin system. The lab discovered important contributions of this system to hematopoiesis, reproduction, cancer immunology and lung injury, in addition to the cardiovascular system. In particular, the lab is investigating the possibility of manipulating this system as a means of increasing immune resistance.

  • Distinguished Scientist, American Heart Association, 2013
  • Member, Association of American Physicians, 2009
  • Basic Research Prize of the American Heart Association, 2007
  • Co-recipient, AHA Novartis Prize for Hypertension Research, 2005
  • Bernstein KE, Fuchs S. Angiotensin II and JAK2 put on the pressure. Nat Med. 2010;16(2):165-166.
  • Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, Giani JF, Nguyen MT, Riquier-Brison AD, Seth DM, Fuchs S, Eladari D, Picard N, Bachmann S, Delpire E, Peti-Peterdi J, Navar LG, Bernstein KE, et al. The absence of intrarenal ACE protects against hypertension. J Clin Invest. 2013;123(5):2011-2023.
  • Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE. Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature. 1991;351(6323):233-236.
  • Okwan-Duodu D, Datta V, Shen XZ, Goodridge HS, Bernstein EA, Fuchs S, Liu GY, Bernstein KE. Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus. J Biol Chem. 2010;285(50):39051-39060.
  • Shen XZ, Billet S, Lin C, Okwan-Duodu D, Chen X, Lukacher AE, Bernstein KE. The carboxypeptidase ACE shapes the MHC class I peptide repertoire. Nat Immunol. 2011 Oct 2;12(11):1078-1085.
  • Shen XZ, Lukacher AE, Billet S, Williams IR, Bernstein KE. Expression of angiotensin-converting enzyme changes major histocompatibility complex class I peptide presentation by modifying C termini of peptide precursors. J Biol Chem. 2008 Apr 11;283(15):9957-9965.

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