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Joshua I. Goldhaber, MD

Associate Director, Coronary Intensive Care Unit

Director, Applied Cell Biology and Physiology

Director, Basic Research in the Heart Institute

Dorothy and E. Phillip Lyon Chair in Laser Research

Joshua I. Goldhaber, MD

Associate Director, Coronary Intensive Care Unit

Director, Applied Cell Biology and Physiology

Director, Basic Research in the Heart Institute

Dorothy and E. Phillip Lyon Chair in Laser Research

  • IM/Cardiology

Critical Care Cardiology

The Goldhaber laboratory studies the regulation of cardiac contractility and sinoatrial node activity. Abnormal contractile function is a key feature of heart failure, a condition which affects over 5 million Americans and is a major driver of health care costs. Sinus node dysfunction is another common disease, which is responsible for 200,000 permanent pacemaker implantations every year and which also contributes to conditions such as atrial fibrillation. Both heart failure and sinus node disease are caused in part by abnormal intracellular calcium cycling. The Goldhaber laboratory studies the basic mechanisms of intracellular calcium cycling, particularly the role of the sodium-calcium exchange transporter, on cardiac muscle contractility and sinus node function. The sodium-calcium exchanger is an electrogenic transporter located on the surface membrane of cardiac cells. It is considered to be the dominant calcium efflux transport mechanism in cardiac cells. The Goldhaber laboratory uses specialized techniques in multiple complementary biological models to study the interaction between calcium regulation and molecular transporter structure/function, ion channel biophysics, calcium signaling and cellular electrophysiology. Methodology includes high speed laser scanning confocal microscopy, voltage mapping, conventional patch clamp, mutagenesis and giant patch.

  • Undergraduate: Harvard College, 1980
  • Medical School: Harvard Medical School, 1984
  • Internship: UCLA Medical Center, Los Angeles, CA, 1985
  • Residency: UCLA Medical Center, Los Angeles, CA, 1987
  • Fellowship: UCLA Medical Center, Los Angeles, CA, 1990
  • Dorothy and E. Phillip Lyon Chair in Laser Research, 2010
  • President, Western Society of Clniical Investigation, 2005 - 2006
  • President, Western Association of Physicians, 2013 - 2014
  • Elected Member, Association of University Cardiologists, 2015
  • Alpha Omega Alpha, 2004
  • Fellow, American College of Cardiology, 1990

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Click here for a list of peer-reviewed publications.

  • Reuter H, Han T, Motter C, Philipson KD, Goldhaber JI: Mice overexpressing the cardiac sodium-calcium exchanger: defects in excitation-contraction coupling. J. Physiol. (Lond.), 554(Pt 3): 779-89, 2003
  • Fukumoto GH, Lamp ST, Motter C, Bridge JH, Garfinkel A, Goldhaber JI: Metabolic inhibition alters subcellular calcium release patterns in rat ventricular myocytes: implications for defective excitation-contraction coupling during cardiac ischemia and failure. Circ. Res., 96(5): 551-7, 2005
  • Chantawansri C, Huynh N, Yamanaka J, Garfinkel A, Lamp ST, Inoue M, Bridge JH, Goldhaber JI: Effect of metabolic inhibition on couplon behavior in rabbit ventricular myocytes. Biophys. J., 94(5): 1656-66, 2007
  • Goldhaber JI, Hamilton MA: Role of inotropic agents in the treatment of heart failure. Circulation, 121(14): 1655-60, 2010
  • Neco P, Rose B, Huynh N, Zhang R, Bridge JH, Philipson KD, Goldhaber JI: Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart. Biophys. J., 99(3): 755-64, 2010
  • Groenke S, Larson ED, Alber S, Zhang R, Lamp ST, Ren X, Nakano H, Jordan MC, Karagueuzian HS, Roos KP, Nakano A, Proenza C, Philipson KD, Goldhaber JI. Complete Atrial-Specific Knockout of Sodium-Calcium Exchange Eliminates Sinoatrial Node Pacemaker Activity. PLoS One. 8:e81633. 2013.

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