Ning-Ai Liu, MD

Assistant Professor, Medicine

Cedars-Sinai Pituitary Center
127 S. San Vicente Blvd.
Advanced Health Sciences Pavilion, Suite A6600
Los Angeles, CA





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Ning-Ai Liu, MD

Assistant Professor, Medicine

  • IM/Endocrinology


Cushing's Disease

Parathyroid Disorders

Pituitary Disorders

Pituitary Tumors


Thyroid Disorders

The research of Ning-Ai Liu, MD, focuses on the developmental and molecular mechanisms underlying hypothalamic-pituitary pathophysiology. Her current research projects seek to identify new therapeutic targets of human pituitary tumor using zebrafish disease model. Major clinical research includes a phase II trial investigating the efficacy and safety of small molecule CDK inhibitor for treatment of Cushing's disease.

  • Medical School: Fudan University Shanghai Medical College, 1985
  • Internship: Medical College of Georgia, 1997
  • Residency: Medical College of Georgia, 1999
  • Fellowship: Cedars-Sinai, 2003
  • Ríos Y, Melmed S, Lin S, Liu NA. Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansion. PLoS Genet. 2011;7(1):e1001271.
  • Huang H, Lindgren A, Wu X, Liu NA, Lin S. High-throughput screening for bioactive molecules using primary cell culture of transgenic zebrafish embryos. Cell Rep. 2012;2(3):695-704.
  • Liu NA, Ren M, Song J, Ríos Y, Wawrowsky K, Ben-Shlomo A, Lin S, Melmed S. In vivo time-lapse imaging delineates the zebrafish pituitary proopiomelanocortin lineage boundary regulated by FGF3 signal. Dev Biol. 2008;319(2):192-200.
  • Liu NA, Araki T, Cuevas-Ramos D, Hong J, Ben-Shlomo A, Tone Y, Tone M, Melmed S. Cyclin E - mediated human proopiomelanocortin regulation as a therapeutic target for Cushing disease. J Clin Endocrinol Metab. 2015;100(7)2557-2564.
  • Xu N, Chua AK, Jiang H, Liu NA, Goodarzi MO. Early embryonic androgen exposure induces transgenerational epigenetic and metabolic changes. Mol Endocrinol. 2014;28(8):1329-1336.
  • Liu NA, Jiang H, Ben-Shlomo A, Wawrowsky K, Fan XM, Lin S, Melmed S. Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor. Proc Natl Acad Sci U S A. 2011;108(20):8414-8419.

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