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Leslie J. Raffel, MD, ABMGG

Associate Director, Common Disease Genetics Program

Director, Clinical and Translational Science Institute

Professor, Pediatrics

Cedars-Sinai Children's Health Center
Spielberg Building
8730 Alden Drive
Los Angeles, CA 90048

Phone:

310-423-9914

Fax:

301-423-2080

Leslie J. Raffel, MD, ABMGG

Associate Director, Common Disease Genetics Program

Director, Clinical and Translational Science Institute

Professor, Pediatrics

  • Medical Genetics
  • Pediatrics

Connective Tissue Diseases

Developmental Delays

Genetic Counseling

Marfan's Syndrome

Neurofibromatosis

Delineation of the genetic basis of susceptibility to common adult-onset diseases, including type 2 (non-insulin dependent) diabetes mellitus and its complications, hypertension and coronary artery disease. Detailed physiological and biochemical studies are used to identify early changes related to a disorder and combined with large scale genotyping to identify genes that predispose to these conditions.

  • Medical School: Medical College of Pennsylvania, 1978
  • Internship: St. Christopher's Hospital for Children, 1979
  • Residency: St. Christopher's Hospital for Children, 1981
  • Fellowship: Harbor-UCLA Medical Center, 1985
  • Clinical Director, Medical Genetics Research Institute, 2013-present
  • Associate Director and Cedars-Sinai Site Director, UCLA Clinical & Translational Science Institute (CTSI), 2011-present
  • Founding Fellow, American College of Medical Genetics, 1991
  • Member, American Society of Human Genetics, 1984
  • Program Director, Cedars-Sinai General Clinical Research Center, 2008-2011
  • Palmer ND, Goodarzi MO, Langefeld CD, Wang N, Guo X, Taylor KD, Fingerlin TE, Norris JM, Buchanan TA, Xiang AH, Haritunians T, Ziegler JT, Williams AH, Stefansovski D, Cui J, Mackay A, Henkin LF, Bergman RN, Gao X, Gauderman J, Varma R, Hanis CL, Cox NJ, Highland HM, Below JE, Williams AL, Burtt NP, Aguilar-Salinas CA, Huerta-Chagoya A, Gonzalez-Villalpando C, Orozco L, Haiman CA, Tsai MY, Johnson WC, Yao J, Rasmussen-Torvik L, Pankow J, Snively B, Jackson RD, Liu S, Nadler JL, Kandeel F, Chen Y-DI, Bowden DW, Rich SS, Raffel LJ, Rotter JI, Watanabe RM, Wagenknecht LE. Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. Diabetes. 2014 Dec 18. pii: DB_140732.
  • Ng MC, Shriner D, Chen BH, Li J, Chen W-M, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ, Jensen RA, Evans DS, Sun YV, An P, Patel SR, Lu Y, Long J, Armstrong LL, Wagenknecht L, Yang L, Snively B, Palmer ND, Mudgal P, Langefeld CD, Keene KL, Freedman BI, Mychaleckyj JC, Nayak Y, Raffel LJ, Goodarzi MO, Chen Y-DI, Taylor JR HA, Correa A, Sims M, Couper D, Pankow JS, Boerwinkle E, Adeyemo A, Doumatey A, Chen G, Mathias RA, Vaidya D, Singleton AB, Zonderman AB, Igo Jr RP, Sedor JR, Kabagambe E, Siscovick DS, McKnight B, Rice K, Liu Y, Hsueh W-C, Zhao W, Bielak LF, Kraja A, Province MA, Bottinger EP, Gottesman O, Cai Q, Zheng W, Blot WJ, Lowe WL, Pacheco JA, Crawford D, Grundberg E, Rich SS, Hayes MG, Shu X-O, Loos RJF, Borecki Ingrid, Peyser PA, Cummings SR, Psaty BM, Fornage M, Iyengar SK, Evans MK, Becker DM, Kao WHL, Wilson JG, Rotter JI, Sale MM, Liu S, Rotimi CN, Bowden DWW: Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes. PLoS Genet. 2014 Aug 7;10(8): e1004517.doi:10.1371/ journal.pgen.1004517
  • Goodarzi MO, Langefeld CD, Xiang AH, Chen Y-DI, Guo X, Hanley AJG, Raffel LJ, Kandeel F, Buchanan TA, Norris JM, Fingerlin TE, Lorenzo C, Rewers MJ, Haffner SM, Bowden DW, Rich SS, Bergman RN, Rotter JI, Watanabe RM, Wagenknecht LE. Insulin Sensitivity and Insulin Clearance Both Have Strong Genetic Correlation in Hispanics. Obesity (Silver Spring). 2014 Apr;22(4):1157-64. doi: 10.1002/oby.20639.
  • Goodarzi MO, Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YD, Taylor KD, Buchanan TA, Hsueh WA, Raffel LJ, Rotter JI: Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance. Diabetologia, 56(6): 1282-90, 2013
  • Coviello AD, Haring R, Wellons M, Vaidya D, Lehtimaki T, Keildson S, Lunetta KL, He C, Fornage M, Lagou V, Mangino M, Onland-Moret NC, Chen B, Eriksson J, Garcia M, Liu YM, Koster A, Lohman K, Lyytikainen LP, Petersen AK, Prescott J, Stolk L, Vandenput L, Wood AR, Zhuang WV, Ruokonen A, Hartikainen AL, Pouta A, Bandinelli S, Biffar R, Brabant G, Cox DG, Chen Y, Cummings S, Ferrucci L, Gunter MJ, Hankinson SE, Martikainen H, Hofman A, Homuth G, Illig T, Jansson JO, Johnson AD, Karasik D, Karlsson M, Kettunen J, Kiel DP, Kraft P, Liu J, Ljunggren O, Lorentzon M, Maggio M, Markus MR, Mellstrom D, Miljkovic I, Mirel D, Nelson S, Morin Papunen L, Peeters PH, Prokopenko I, Raffel L, Reincke M, Reiner AP, Rexrode K, Rivadeneira F, Schwartz SM, Siscovick D, Soranzo N, Stockl D, Tworoger S, Uitterlinden AG, van Gils CH, Vasan RS, Wichmann HE, Zhai G, Bhasin S, Bidlingmaier M, Chanock SJ, De Vivo I, Harris TB, Hunter DJ, Kahonen M, Liu S, Ouyang P, Spector TD, van der Schouw YT, Viikari J, Wallaschofski H, McCarthy MI, Frayling TM, Murray A, Franks S, Jarvelin MR, de Jong FH, Raitakari O, Teumer A, Ohlsson C, Murabito JM, Perry JR: A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. PLoS Genet., 8(7): e1002805, 2012

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