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Robert H. Baloh, MD, PhD

Associate Professor, Neurology

Director, Neuromuscular Medicine

Advanced Health Sciences Pavilion
127 S San Vicente Blvd., A6600
Los Angeles, CA 90048

Phone:

310-423-6472

Fax:

310-967-0601

Parking Instructions:

Validates Cedars-Sinai Medical Center parking only. Nearest lot is Lot 4 on Sherbourne Dr

Robert H. Baloh, MD, PhD

Associate Professor, Neurology

Director, Neuromuscular Medicine

  • Neurology

ALS (Lou Gehrig's Disease)

Cervical Myelopathy

Charcot-Marie-Tooth Disease (CMT)

Chronic Inflammatory Demyelinating Polyneuropathy-CIDP

Guillain-Barre Syndrome

Inclusion-Body Myositis

Lumbar Puncture

Musculoskeletal Disorders

Myasthenia Gravis

Myositis

Nerve Injury / Injuries

Neuromuscular Disorders

Neuropathy

Polyneuropathy

Thoracic Myelopathy

The overall goal of my laboratory is to understand the molecular mechanisms of neuromuscular diseases using in vitro and animal modeling, based on insights from human genetics, to develop novel therapeutic agents. We are particularly interested in inherited neuropathy (Charcot-Marie-Tooth disease), and amyotrophic lateral sclerosis (ALS). The molecular pathways defined by genes mutated in hereditary neuromuscular diseases provide insight into molecular pathogenesis, and are potential candidates for therapeutic manipulation. To investigate mechanisms of motor neuron disease/ALS we are exploring the role of mutations in both the repeat expansion in the C9ORF72 gene, and point mutations in the TARDBP gene, using human induced pluripotent stem cell (iPSC)-derived motor neurons and mouse models. To investigate Charcot-Marie-Tooth disease we are studying (i) the mechanism of mutations in the Mitofusin 2 gene in axonal CMT, and (ii) the use of iPSC-derived Schwann cells from patients with CMT type 1A (the most common genetic form) to both model the disease in vitro, and for use in potential transplantation therapy in humans.Neurodegenerative and neuromuscular disorders, with an emphasis on (1) amyotrophic lateral sclerosis (ALS), commonly referred to as Lou Gehrig's disease, and (2) inherited neuropathy or Charcot-Marie-Tooth disease.

  • Internship: Brigham and Women's Hospital, 2002
  • Medical School: Washington University School of Medicine, 2005
  • Residency: Brigham and Women's Hospital, 2005
  • Fellowship: Washington University School of Medicine, 2006
  • Prize for Research in Scientific Medicine, Cedars-Sinai, 2016
  • Washington University Distinguished Investigator Award, 2011
  • S. Weir Mitchell Award, American Academy of Neurology, 2007

Click here for a list of peer-reviewed publications.

  • Cady J, Allred P, Bali T, Pestronk A, Goate A, Miller TM, Mitra R, Ravits J, Harms MB, Baloh RH. Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes. Ann Neurol. 2015 Jan;77(1):100-113.
  • Udan-Johns M, Bengoechea R, Bell S, Shao J, Diamond MI, True HL, Weihl CC, Baloh RH. Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones. Hum Mol Genet. 2014 Jan 1;23(1):157-170.
  • Sareen D, Gire-O’Rourke J, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, Sahabian A, Gendron T, Petrucelli L, Baughn M, Ravits J, Harms MB, Rigo F, Bennett CF, Svendsen CN, Baloh RH. Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion. Science Translational Medicine. 23 October 2013: Vol. 5, Issue 208, p. 208ra149.

English

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