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Dmitriy Sheyn, PhD

Assistant Professor, Orthopaedics

Assistant Professor, Surgery

Assistant Professor, Biomedical Sciences

Dmitriy Sheyn, PhD

Phone:

424-315-4579

Dmitriy Sheyn, PhD

Assistant Professor, Orthopaedics

Assistant Professor, Surgery

Assistant Professor, Biomedical Sciences

The work of Dmitriy Sheyn, PhD, focuses on the regeneration of the intervertebral disc, bone and soft tissues using adult and induced pluripotent stem cells. Degenerative disease of the intervertebral disc and associated chronic lower back pain constitute a major health problem with estimated costs in the U.S. of up to $50 billion yearly. Despite decades of research, no fundamental multidisciplinary understanding of the mechanisms of disc degeneration has surfaced. Consequently, clinical therapies are still in the earliest stages of development. The main challenge now is to develop new stem cell therapies for the intervertebral disc and use appropriate animal models that can lead to future clinical practice. Genetically engineered stem cells are a tool for tissue engineering and regenerative medicine, albeit a tool whose development is fraught with difficulties. Gene-and-cell therapy offers solutions to severe problems faced by modern medicine, but several impediments obstruct the path of such treatments as they move from the laboratory toward the clinical setting. One of the main focuses of Sheyn's research was to develop gene-and-stem cell therapy for bone tissue related disorders. He and his colleagues have developed an efficient and easily reproducible method of modifying stem cells to regenerate bone fractures and generate new bone tissue and repair vertebral compression fractures. Their studies have demonstrated that the bone marrow-derived, adipose tissue-derived and induced pluripotent stem cells overexpressing osteogenic factors can repair significant defects and injuries in the long bones, calvarial defects and vertebral body problems that otherwise would be incurable. They developed a systemic stem cell therapy that repaired vertebral bone defects in osteoporotic rats and in large animal models. Recently, Sheyn has focused his research on using induced pluripotent stem cells for bone soft tissues and spine regeneration.

View NIH Biographical Sketch

  • Undergraduate: Hebrew University of Jerusalem, 2004
  • Master's: Hebrew University of Jerusalem, 2005
  • Doctorate: Hebrew University of Jerusalem, 2011
  • Post Doctorate: Cedars-Sinai, 2013
  • Biomedical Sciences
  • Surgery
  • Regenerative Medicine Institute (Board of Governors Regenerative Medicine Institute)

English

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