Robin M. Shaw, MD, PhD

Wasserman Foundation Chair in Cardiology in honor of S. Rexford Kennamer MD

Robin M. Shaw, MD, PhD

Wasserman Foundation Chair in Cardiology in honor of S. Rexford Kennamer MD

  • IM/Cardiology


Coronary Artery Disease (CAD)

Heart Attack (Myocardial Infarction)

Heart Disease

Heart Murmurs

Heart Valve Diseases

Molecular mechanisms of heart arrhythmias and heart failure progression. We focus on cardiac ion channel formation and trafficking, with particular emphasis on Connexin43 gap junctions and L-type calcium channels. In a ""cell to bedside"" approach, we are translating our basic findings into novel diagnostics and therapeutics for failing hearts.

  • Medical School: Case Western Reserve University School of Medicine, 1999
  • Residency: University of California (San Francisco) Medical Center, 2001
  • Fellowship: University of California (San Francisco) Medical Center, 2004
  • Editorial Board: Trends in Cardiovascular Medicine, Current
  • Established Investigator Award, American Heart Association, 2013
  • Golden Stethoscope Award, Division of Cardiology, UCSF, 2003
  • Member, American Society for Clinical Investigation, 2014
  • Study Section, American Heart Association, 2006
  • Study Section, Nation Science Foundation, 2007
  • Study Section, National Institutes of Health, 2010, 2015

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  • Shaw RM. Desmosomal hotspots, microtubule delivery, and cardiac arrhythmogenesis. Dev Cell 2014;31:139-40.
  • Hong T, Yang H, Zhang SS, Cho HC, Kalashnikova M, Sun B, Zhang H, Bhargava A, Grabe M, Olgin J, Gorelik J, Marb�E, Jan LY, Shaw RM: Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. Nat. Med., 20(6): 624-32, 2014
  • Smyth JW, Shaw RM: Autoregulation of connexin43 gap junction formation by internally translated isoforms. Cell Rep, 5(3): 611-8, 2013
  • Smyth JW, Vogan JM, Buch PJ, Zhang SS, Fong TS, Hong TT, Shaw RM: Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane. Circ. Res., 110(7): 978-89, 2012
  • Hong TT, Smyth JW, Gao D, Chu KY, Vogan JM, Fong TS, Jensen BC, Colecraft HM, Shaw RM: BIN1 localizes the L-type calcium channel to cardiac T-tubules. PLoS Biol., 8(2): e1000312, 2010
  • Smyth JW, Hong TT, Gao D, Vogan JM, Jensen BC, Fong TS, Simpson PC, Stainier DY, Chi NC, Shaw RM: Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. J. Clin. Invest., 120(1): 266-79, 2009

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