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Rivkah Gonsky, PhD

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Rivkah Gonsky, PhD

The research of Rivkah Gonsky, PhD, focuses on defining the molecular mechanisms involved in dysregulated T cell activation and cytokine secretion in inflammatory bowel disease (IBD). An integrative approach is utilized employing molecular, cellular, genetic and epigenetic studies from human tissue specimens with the goal to identify potential molecular therapeutic targets to aid in sub-stratification of IBD patients for prognostics and personalized-medicine based therapies.

  • Society of Mucosal Immunology, 2004
  • American Gastroenterological Association, 1998
  • Gonsky R, Fleshner P, Deem RL, Biener-Ramanujan E, Li D, Potdar AA, Bilsborough J, Yang S, McGovern DPB, Targan SR. Association of Ribonuclease T2 Gene Polymorphisms with Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease. Gastroenterology. 2017 Jul;153(1):219-232. PubMed Central PMCID: PMC5484733.
  • Gonsky R, Deem RL, Landers CJ, Haritunians T, Yang S, Targan SR. IFNG rs1861494 Polymorphism is Associated with IBD Disease Severity and Functional Changes in both IFNG Methylation and Protein Secretion. Inflamm Bowel Dis. 2014 Oct; 20(10): 1794-1801. PubMed Central PMCID: PMC4327845.
  • Gonsky R, Deem RL, Landers CJ, Derkowski CA, Berel D, McGovern DP, Targan SR. Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens. Inflamm Bowel Dis. 2011 Jan;17(1):171-8. PMID: 20848535. PubMed Central PMCID: PMC3400263.
  • Gonsky R, Deem RL, Targan SR. Distinct Methylation of IFNG in the Gut. J Interferon Cytokine Res. 2009 Jul;29(7):407-14. PMID: 19450149. PubMed Central PMCID: PMC2956574.

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