The laboratory of Cory Hogaboam, PhD, is focused on elucidating innate and adaptive immune mechanisms that drive chronic lung diseases such as asthma, hypersensitivity pneumonitis, chronic obstructive pulmonary disease (COPD), and idiopathic interstitial pneumonias (IIPs; like idiopathic pulmonary fibrosis). Lab members are particularly interested in understanding the manner in which lung structural cells are impacted by these disease processes.

• Cancer Institute (Samuel Oschin Comprehensive Cancer Institute)

• American Journal of Respiratory and Critical Care Medicine, Current
• American Association of Asthma, Allergy & Immunology, 2013
• Journal of Immunology, 2002-09
• American Thoracic Society, 2002
• American Society for Investigative Pathologists, 2001
• American Association of Immunologists, 1999

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• Ellson CD, Dunmore R, Hogaboam CM, Sleeman MA, Murray LA. Danger-associated molecular patterns and danger signals in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 2014 Aug;51(2):163-168.
• Moreira AP, Cavassani KA, Ismailoglu UB, Hullinger R, Dunleavy MP, Knight DA, Kunkel SL, Uematsu S, Akira S, Hogaboam CM. The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A. J Clin Invest. 2011 Nov;121(11):4420-4432.
• Murray LA, Zhang H, Oak SR, Coelho AL, Herath A, Flaherty KR, Lee J, Bell M, Knight DA, Martinez FJ, Sleeman MA, Herzog EL, Hogaboam CM. Targeting interleukin-13 with tralokinumab attenuates lung fibrosis and epithelial damage in a humanized SCID idiopathic pulmonary fibrosis model. Am J Respir Cell Mol Biol. 2014 May;50(5):985-994.
• Shibata T, Habiel DM, Coelho AL, Kunkel SL, Lukacs NW, Hogaboam CM. Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma. J Immunol. 2014 Apr 15;192(8):3569-3581.
• Trujillo G, Meneghin A, Flaherty KR, Sholl LM, Myers JL, Kazerooni EA, Gross BH, Oak SR, Coelho AL, Evanoff H, Day E, Toews GB, Joshi AD, Schaller MA, Waters B, Jarai G, Westwick J, Kunkel SL, Martinez FJ, Hogaboam CM. TLR9 differentiates rapidly from slowly progressing forms of idiopathic pulmonary fibrosis. Sci Transl Med. 2010 Nov 10;2(57):57ra82.

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