Eggehard Holler, PhD

Professor, Neurosurgery

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Eggehard Holler, PhD

Professor, Neurosurgery

The research of Eggehard Holler, PhD, focuses on design, synthesis and characterization of novel nanoscale drug delivery systems based on polymalic acid. These "nano drugs" are single macromolecules, which are applicable in personalized medicine especially cancer treatment. They provide targeting of tumor markers and an array of prodrugs which are activated at the site of targeted cells in resonse of specific cellular stimuli. The nanomedicine was established in preclinical models of solid breast and brain tumors and for brain metastases and is prepared for translation into clinics. After appropriate modifications, the nanomaterial was transformed into reagents for differential diagnosis by MRI of solid and metastatic brain tumors. Research grants: NIH/NCI R01 CA123495; NIH/NCI R01 CA136841; NIH/NCI, U01 CA151815; The Martz Translational Breast Cancer Research Fund. In addition, grants by PB/SCAQMD; BTAP007 AQMD on traffic air pollution, such as heavy metals acquired by breathing and activation of signal pathways that might lead to brain malignancies.

View NIH Biographical Sketch as a PDF

  • Doctorate: Institute of Physical Chemistry, Goethe University Frankfurt, 1968
  • Post Doctorate: Cornell University, 1969
  • Post Doctorate: University of California, Berkley, 1971
  • Editor: British Microbiology Research Journal, 2013
  • American Assiociation of Cancer, 1987
  • German Society for Cell Biology, 1985
  • German Society for Molecular Biology, 1973

Click here for a list of peer-reviewed publications.

  • Ding H, Portilla-Arias J, Patil R, Black KL, Ljubimova JY, Holler E. Distinct mechanisms of membrane permeation induced by two polymalic acid copolymers. Biomaterials. 2012;34(1):217-225.
  • Fischer H, Erdmann S, Holler E. An unusual polyanion from Physarum polycephalum that inhibits homologous DNA polymerase-alpha in vitro. Biochemistry. 1989;28(12):5219-5226.
  • Lee B-S, Vert M, Holler E. Water-soluble aiiphatic polyesters: poly(malic acid)s. Biopolymers. 2005;3:75-103.
  • Patil R, Ljubimov AV, Gangalum PR, Ding H, Portilla-Arias J, Wagner S, Inoue S, Konda B, Rekechenetskiy A, Chesnokova A, Markman JL, Ljubimov VA, Li D, Prasad RS, Black KL, Holler E, et al. MRI virtual biopsy and treatment of brain metastatic tumors with targeted nanobioconjugates: nanoclinic in the brain. ACS Nano. 2015;9(5):5594-5608.
  • Inoue S, Ding H, Portilla-Arias J, Hu J, Konda B, Fujita M, Espinoza A, Suhane S, Riley M, Gates M, Patil R, Penichet ML, Ljubimov AV, Black KL, Holler E, et al. Polymalic acid-based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity. Cancer Res. 2011;71(4):1454-1464.
  • Holler E. Mechanism of Action of Tumor-Inhibiting Metal Complexes. In: Keppler BK, ed. Metal Complexes in Cancer Chemotherapy. 1st ed. New York, NY: VCH Publishers; 1993:39-71.
  • Ding H, Portilla-Arias J, Patil R, Black KL, Ljubimova JY, Holler E. The optimization of polymalic acid peptide copolymers for endosomolytic drug delivery. Biomaterials. 2011;32(22):5269-5278.
  • Ljubimova JY, Portilla-Arias J, Patil R, Ding H, Inoue S, Markman JL, Rekechenetskiy A, Konda B, Gangalum PR, Chesnokova A, Ljubimov AV, Black KL, Holler E. Toxicity and efficacy evaluation of multiple targeted polymalic acid conjugates for triple-negative breast cancer treatment. J Drug Target. 2013;21(10):956-967.
  • Ljubimova YJ, Fujita M, Ljubimov AV, Torchilin VP, Black KL, Holler E. Biodegradable multitargeting nanoconjugates for drug delivery. Nanomedicine (Lond). 2008;3(2):247-265.

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