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Ting-Ting Hong, MD, PhD

Associate Professor, Medicine

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310-423-4785

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310-967-3891

Ting-Ting Hong, MD, PhD

Associate Professor, Medicine

The research of TingTing Hong, MD, PhD, focuses on cardiac membrane organization and function, with particular interests on T-tubule microdomain function and regulation.

  • Medical School: Peking University, 1997
  • Residency: Peking University, 2000
  • Doctorate: University of Michigan, 2005
  • Fellow-to-faculty Award, National Institutes of Health, 2012

Click here for a list of peer-reviewed publications.

  • Fu Y, Shaw SA, Naami R, Vuong CL, Basheer WA, Guo X, Hong T. Isoproterenol Promotes Rapid Ryanodine Receptor Movement to Bridging Integrator 1 (BIN1) – Organized Dyads. Circulation. 2016; 133:388-397
  • Hong TT, Yang H, Zhang SS, Cho HC, Kalashnikova M, Sun B, Zhang H, Bhargava A, Grabe M, et al. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. Nat Med. 2014 Jun;20(6):624-632
  • Hong TT, Cogswell R, James CA, Kang G, Pullinger CR, Malloy MJ, Kane JP, Wojciak J, Calkins H, et al. Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm. 2012 Jun;9(6):961-967.
  • Hong TT, Smyth JW, Chu KY, Vogan JM, Fong TS, Jensen BC, Fang K, Halushka MK, Russell SD, et al. BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. Heart Rhythm. 2012 May;9(5):812-820.
  • Hong TT, Smyth JW, Gao D, Chu KY, Vogan JM, Fong TS, Jensen BC, Colecraft HM, Shaw RM. BIN1 localizes the L-type calcium channel to cardiac T-tubules. PLoS Biol. 2010 Feb 16;8(2):e1000312.
  • Smyth JW, Hong TT, Gao D, Vogan JM, Jensen BC, Fong TS, Simpson PC, Stainier DY, Chi NC, Shaw RM. Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. J Clin Invest. 2010 Jan;120(1):266-279.
  • Smyth JW, Vogan JM, Buch PJ, Zhang SS, Fong TS, Hong TT, Shaw RM. Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane. Circ Res. 2012 Mar 30;110(7):978-989.

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