Morvarid Kabir, PhD

Assistant Professor, Biomedical Sciences

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Morvarid Kabir, PhD

Assistant Professor, Biomedical Sciences

There is an abundance of evidence demonstrating the association of obesity, in particular central or intra-abdominal obesity, with a cluster of metabolic disorders, such as insulin resistance, type 2 diabetes, dyslipidemia, hypertension and nonalcoholic steatohepatitis. The research goal of our laboratory is to understand the molecular regulation of adipose tissue from different anatomical depots, and why intra-abdominal obesity is associated with the whole body and hepatic insulin resistance. In our laboratory, we utilize molecular and cellular techniques to examine the interplay between adipose tissue and the liver during insulin resistance and obesity using interventions such as fat feeding and insulin sensitizing drugs such as a selective endocannabinoid receptor antagonist. Recently, we are interested to study expression of the genes involved in thermogenesis and fat browning by CB1 antagonists.

  • Doctorate: Pierre and Marie Curie University, 1998

Click here for a list of peer-reviewed publications.

  • Kabir M, Iyer MS, Richey JM, Woolcott OO, Asare Bediako I, Wu Q, Kim SP, Stefanovski D, Kolka CM, Hsu IR, et al. CB1R antagonist increases hepatic insulin clearance in fat-fed dogs likely via upregulation of liver adiponectin receptors. Am J Physiol Endocrinol Metab. 2015 Oct 15;309(8):E747-758.
  • Kabir M, Stefanovski D, Hsu IR, Iyer M, Woolcott OO, Zheng D, Catalano KJ, Chiu JD, Kim SP, Harrison LN, et al. Large size cells in the visceral adipose depot predict insulin resistance in the canine model. Obesity (Silver Spring). 2011;19(11):2121-2129.
  • Woolcott OO, Richey JM, Kabir M, Chow RH, Iyer MS, Kirkman EL, Stefanovski D, Lottati M, Kim SP, Harrison LN, et al. High-Fat Diet-Induced Insulin Resistance does not Increase Plasma Anandamide Levels or Potentiate Anandamide Insulinotropic Effect in Isolated Canine Islets. PLoS One. 2015 Apr 9;10(4):e0131033.
  • Kabir M, Catalano KJ, Ananthnarayan S, Kim SP, Van Citters GW, Dea MK, Bergman RN. Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. Am J Physiol Endocrinol Metab. 2005;288(2):E454-461.
  • Kabir M, Skurnik G, Naour N, Pechtner V, Meugnier E, Rome S, Quignard-Boulangé A, Vidal H, Slama G, Clément K, et al. Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study. Am J Clin Nutr. 2007;86(6):1670-1679.
  • Richey JM, Woolcott OO, Stefanovski D, Harrison LN, Zheng D, Lottati M, Hsu IR, Kim SP, Kabir M, Catalano KJ, et al. Rimonabant prevents additional accumulation of visceral and subcutaneous fat during high-fat feeding in dogs. Am J Physiol Endocrinol Metab. 2009;296(6):E1311-1318.

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