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Dmitriy Sheyn, PhD

Assistant Professor, Orthopaedics

Assistant Professor, Surgery

Assistant Professor, Biomedical Sciences

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Dmitriy Sheyn, PhD

Assistant Professor, Orthopaedics

Assistant Professor, Surgery

Assistant Professor, Biomedical Sciences

The work of Dmitriy Sheyn, PhD, focuses on the regeneration of the intervertebral disc, bone and soft tissues using adult and induced pluripotent stem cells. Degenerative disease of the intervertebral disc and associated chronic lower back pain constitute a major health problem with estimated costs in the U.S. of up to $50 billion yearly. Despite decades of research, no fundamental multidisciplinary understanding of the mechanisms of disc degeneration has surfaced. Consequently, clinical therapies are still in the earliest stages of development. The main challenge now is to develop new stem cell therapies for the intervertebral disc and use appropriate animal models that can lead to future clinical practice. Genetically engineered stem cells are a tool for tissue engineering and regenerative medicine, albeit a tool whose development is fraught with difficulties. Gene-and-cell therapy offers solutions to severe problems faced by modern medicine, but several impediments obstruct the path of such treatments as they move from the laboratory toward the clinical setting. One of the main focuses of Sheyn's research was to develop gene-and-stem cell therapy for bone tissue related disorders. He and his colleagues have developed an efficient and easily reproducible method of modifying stem cells to regenerate bone fractures and generate new bone tissue and repair vertebral compression fractures. Their studies have demonstrated that the bone marrow-derived, adipose tissue-derived and induced pluripotent stem cells overexpressing osteogenic factors can repair significant defects and injuries in the long bones, calvarial defects and vertebral body problems that otherwise would be incurable. They developed a systemic stem cell therapy that repaired vertebral bone defects in osteoporotic rats and in large animal models. Recently, Sheyn has focused his research on using induced pluripotent stem cells for bone soft tissues and spine regeneration.

View NIH Biographical Sketch as a PDF

  • Undergraduate: Hebrew University of Jerusalem, 2004
  • Master's: Hebrew University of Jerusalem, 2005
  • Doctorate: Hebrew University of Jerusalem, 2011
  • Post Doctorate: Cedars-Sinai, 2013
  • Finalist, New Investigator Research Award, Orthopedic Research Society (ORS) Annual Meeting, 2017
  • Finalist, New Investigator Research Award, Orthopedic Research Society (ORS) Annual Meeting, 2014
  • Best Basic Science Paper at the 16th Annual Scientific Meeting of the International Spine Intervention Society, 2008
  • Rusk Foundation Travel Award for Excellent Graduate Students to Participate in a Scientific Meeting Related to Human Diseases, 2008
  • The Kaye Innovation Award at Hebrew University of Jerusalem, 2007

Click here for a list of peer-reviewed publications.

  • Bez M, Zhou Z, Sheyn D, Tawackoli W, Giaconi JC, Shapiro G, Ben David S, Gazit Z, Pelled G, Li D, Gazit D. Molecular pain markers correlate with pH-sensitive MRI signal in a pig model of disc degeneration. Sci Rep. 2018;8:17363.
  • Sheyn D, Shapiro G, Tawackoli W, Jun DS, Koh Y, Su S, Da X, Ben-David S, Bez M, Yalon E, et al. PTH Induces Systemically Administered Mesenchymal Stem Cells to Migrate to and Regenerate Spine Injuries. Mol Thera. 2016;24(2):318-330.
  • Sheyn D, Ben-David S, Shapiro G, De Mel S, Bez M, Ornelas L, Sahabian A, Sareen D, Da X, Pelled G, et al. Human iPSCs differentiate into functional MSCs and repair bone defect. Stem Cells Transl Med. 2016.
  • Sheyn D, Cohn-Yakubovich D, Kallai K, Su S, Pelled G, Tawackoli W, Gazit D, Gazit Z. PTH promotes allograft integration in a calvarial bone defect. Mol Pharm. 2013;2;10(12):4462-4471.
  • Mizrahi O, Sheyn D, Tawackoli W, Ben-David S, Su A, Li N, Oh A, Bae H, Gazit D, Gazit Z. Nucleus pulposus degeneration alters properties of resident progenitor cells. Spine J. 2013;13(7):803-814.

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