Brennan M. Spiegel, MD

Director, Health Services Research in Academic Affairs and Clinical Transformation

Professor, Medicine

8723 W. Alden Drive
Steven Spielberg Building
Los Angeles, CA 90048

Brennan M. Spiegel, MD

Director, Health Services Research in Academic Affairs and Clinical Transformation

Professor, Medicine

  • IM/Gastroenterology
  • General Gastroenterology

Celiac Disease





Gastroesophageal Reflux (GERD)


Irritable Bowel Syndrome (IBS)

Peptic Ulcers

Stomach Disorders (Nausea, Pain, Vomiting)

Swallowing Disorders (Dysphagia)

Brennan Spiegel, MD, is the director of Cedars-Sinai Health Services Research. He directs the Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), a multidisciplinary team that investigates how digital health technologies — including wearable biosensors, smartphone applications, virtual reality and social media — can strengthen the patient-doctor bond, improve outcomes and save money. CS-CORE unites clinicians, computer scientists, engineers, statisticians and health services researchers to invent, test and implement digital innovations, always focusing on the value of technology to patients and their providers. Spiegel has published numerous best-selling medical textbooks, editorials and more than 160 articles in peer-reviewed journals. He is listed in the 2016 Onalytica "Top 100 Influencer" lists for digital health (No. 13) and virtual reality (No. 14). His digital health research has been featured by major media outlets, including NBC News, PBS, Forbes, Bloomberg, NPR and Reuters. Beyond his focus on digital health innovations, Spiegel conducts psychometric, health-economic, epidemiologic and qualitative research across a wide range of healthcare topics. As a member of the U.S. Food and Drug Administration Field Advisory Committee, Spiegel also develops endpoints for clinical trials. His research team receives funding from the National Institutes of Health, Robert Wood Johnson Foundation, Hearst Foundation, Veterans Administration and industry sources. Spiegel is editor-in-chief of the American Journal of Gastroenterology, the leading clinical gastroenterology journal in North America. He continues to practice clinical medicine and maintains a busy academic teaching practice at Cedars-Sinai. A prolific speaker, Spiegel is frequently invited to present on his areas of expertise at national and international events.

View NIH Biographical Sketch as a PDF

  • Undergraduate: Tufts University, 1994
  • Medical School: New York Medical College, 1998
  • Residency: Cedars-Sinai, 2001
  • Fellowship: David Geffen School of Medicine at UCLA, 2004
  • Master's: UCLA Fielding School of Public Health, 2004

View CV as a PDF

  • Editor-in-Chief, American Journal of Gastroenterology, 2015 to Present
  • Outstanding Research Paper of 2013, American Society of Gastrointestinal Endoscopy, 2013
  • Appointed as Fellow of the American Gastroenterological Association, 2011
  • Appointed to FDA Gastroenterology Field Advisory Board, 2008
  • Appointed as Fellow of the American College of Gastroenterology, 2008
  • Emerging Leaders in Gastroenterology Award, 2004
  • Veterans Affaris Research Career Development Award, 2004
  • Janssen Research Excellence in Gastroenterology and Liver Award, 2003
  • Leo G Rigler Award for "Resident of the Year", Cedars-Sinai, 1998
  • Alpha Omega Alpha National Honors Society, 1997

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Click here for a list of peer-reviewed publications.

  • Spiegel BM, Hays RD, Bolus R, Melmed GY, Chang L, Whitman C, Khanna PP, Paz SH, Hays T, Reise S, et al. Development of the NIH Patient-Reported Outcomes Measurement Information System (PROMIS) gastrointestinal symptom scales. Am J Gastroenterol. 2014;110(14):608.
  • Spiegel BM, Khanna D, Bolus R, Agarwal N, Khanna P, Chang L. Understanding gastrointestinal distress: a framework for clinical practice. Am J Gastroenterol. 2011;106(3):380-385.
  • Spiegel BM, Kaneshiro M, Russell MM, Lin A, Patel A, Tashjian VC, Zegarski V, Singh D, Cohen SE, Reid MW, et al. Validation of an acoustic gastrointestinal surveillance biosensor for postoperative ileus. J Gastrointest Surg. 2014;18(10):1795-1803.
  • Spiegel BM, DeRosa VP, Gralnek IM, Wang V, Dulai GS. Testing for celiac sprue in diarrhea-predominant irritable bowel syndrome: a cost-effectiveness analysis. Gastroenterology. 2004;126(7):1721-1732.
  • Chan M; Cohen H; Spiegel BM. Colonoscopy yields fewer polyps as the day progresses: Experience in a Veteran Administration teaching hospital. Clin Gastroenterol Hepatol. 2009;7(11):1217-1223.
  • Almario CV, Chey W, Kaung A, Whitman C, Fuller G, Reid M, Nguyen K, Bolus R, Dennis B, Encarnacion R, Martinez B, Talley J, Modi R, Agarwal N, Lee A, Kubomoto S, Sharma G, Bolus S, Chang L, Spiegel BM. Computer-generated vs. physician-documented history of present illness (HPI): results of a blinded comparison. Am J Gastroenterol. 2015;110(1):170-179.

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