Samuel J. Klempner, MD

Assistant Professor, Medicine

The Angeles Clinic and Research Institute
11818 Wilshire Blvd.
Los Angeles, CA 90025





Parking Instructions:

Valet is available in the garage off Granville Avenue and Wilshire Blvd.

Samuel J. Klempner, MD

Assistant Professor, Medicine

  • IM/Hematology/Oncology
  • Gastrointestinal Oncology

Anal Cancers

Bile Duct Cancers

Colorectal Cancer (Colon, Rectal)

Esophageal Cancers

Gallbladder Cancers

Liver Cancers

Lung Cancers

Stomach (Gastric) Cancers

Thoracic Malignancies

Samuel J Klempner, MD, is a medical oncologist with a focus in gastrointestinal malignancies, oncogene driven tumors and clinical trials. His clinical and translational research is focused on cancer genomics, acquired resistance to targeted therapies and the intersection of genomics and immune mediated therapies to identify novel therapies.

  • Undergraduate: Hamilton College, 2003
  • Medical School: University of Massachusetts School of Medicine, 2007
  • Internship: Brigham and Women's Hospital, Harvard Medical School, 2008
  • Residency: Brigham and Women's Hospital, Harvard Medical School, 2010
  • Fellowship: Beth Israel Deaconess Medical Center, Harvard Medical School, 2013
  • Super Doctors Southern California Rising Star, 2016
  • Standing Ovation Award, Cedars-Sinai, 2016
  • Kim ST, Kim SY, Klempner SJ, Yoon J, Kim N, Ahn S, Bang H, Kim KM, Park W, Park SH, et al. Rapamycin-insensitive companion of mTOR (RICTOR) Amplification Defines a Subset of Advanced Gastric Cancer and is Sensitive to AZD2014-mediated mTORC1/2 Inhibition. Ann Oncol. 2016 Dec 27. [Epub ahead of print]
  • Klempner SJ, Gershenhorn B, Tran P, Lee TK, Erlander MG, Gowen K, Schrock AB, Morosini D, Ross JS, Miller VA, et al. BRAFV600E Mutations in High-Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF-MEK Combination Therapy. Cancer Discov. 2016 Jun;6(6):594-600.
  • Klempner SJ, Bordoni R, Gowen K, Kaplan H, Stephens PJ, Ou SH, Ali SM. Identification of BRAF Kinase Domain Duplications Across Multiple Tumor Types and Response to RAF Inhibitor Therapy. JAMA Oncol. 2016 Feb;2(2):272-274.
  • Ali SM, Sanford EM, Klempner SJ, Rubinson DA, Wang K, Palma NA, Chmielecki J, Yelensky R, Palmer GA, Morosini D, et al. Prospective comprehensive genomic profiling of advanced gastric carcinoma cases reveals frequent clinically relevant genomic alterations and new routes for targeted therapies. Oncologist. 2015 May;20(5):499-507.
  • Le Rolle A-F, Klempner SJ, Garrett C, Seery T, Sanford E, Balasubramanian S, Ross J, Stephens P, Miller VA, Ali SM, et al. Identification and characterization of RET fusions in advanced colorectal cancer. Oncotarget. 2015 Oct 6;6(30):28929-28937.
  • Wang K, Johnson A, Ali SM, Klempner SJ, Bekaii-Saab T, Vacirca JL, Khaira D, Yelensky R, Chmielecki J, Elvin JA, et al. Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences. Oncologist. 2015 Oct;20(10):1132-1139.

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