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Dechen Lin, PhD

Assistant Clinical Professor, Medicine

Assistant Professor, Department of Medicine

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Dechen Lin, PhD

Assistant Clinical Professor, Medicine

Assistant Professor, Department of Medicine

Dechen Lin, PhD, has a broad background in cancer, genetics and biology. He has specific training and expertise in functional genomic study, as well as transcriptional regulation. The major focus of Lin’s work is identifying key genomic and epigenomic abnormalities in human malignancies and translating these findings into novel clinical managements. To facilitate this research, he established and developed a variety of functional genomic approaches as well as computational algorithms. With these tools and comprehensive biological studies, he uncovered important genomic aberrations which promote malignant phenotypes, including gene amplifications [Clin Cancer Res 2011], deletions [PNAS 2013; Cancer Res 2015], somatic mutations [Blood 2012; Nature Genetics 2014a; Nature Genetics 2014b] as well as epigenetic lesions [Gut 2016].

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  • Incorporated Scholar-in-Training Award, AACR-Aflac
  • Donna and Jesse Garber Awards for Cancer Research
  • American Society of Hematology (ASH) Fellow Scholar Award
  • MDS Young Investigator Award
  • Lin DC*, Mayakonda A, Dinh HQ, Huang P, Lin L, Liu X, Ding LW, Wang J, Berman B, Song E, et al. Genomic and epigenomic heterogeneity of hepatocellular carcinoma. Cancer Res. 2017 February. [Epub ahead of print] *Correspondence
  • Hao JJ, Lin DC, Dinh HQ, Mayakonda A, Jiang YY, Chang C, Jiang Y, Lu CC, Shi ZZ, Xu X, et al. Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. Nat Genet. 2016 Dec;48(12):1500-1507.
  • Lin DC, Xu L, Ding LW, Sharma A, Liu LZ, Yang H, Tan P, Vadgama J, Karlan BY, Lester J, et al. Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6109-6114.
  • Jiang YY, Lin DC, Mayakonda A, Hazawa M, Ding LW, Chien WW, Xu L, Chen Y, Xiao JF, Senapedis W, et al. Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma. Gut. 2016 May 10. [Epub ahead of print]
  • Lin DC, Meng X, Hazawa M, Nagata Y, Varela AM, Xu L, Sato Y, Liu LZ, Ding LW, Sharma A, et al. The genomic landscape of nasopharyngeal carcinoma. Nat Genet. 2014 Aug;46(8):866-871.
  • Lin DC, Hao JJ, Nagata Y, Xu L, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, Ding LW, et al. Genomic and molecular characterization of esophageal squamous cell carcinoma. Nat Genet. 2014 May;46(5):467-473.

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