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Dan Theodorescu, MD, PhD

PHASE ONE Foundation Distinguished Chair

Director, Cedars-Sinai Cancer

Professor, Surgery

Professor, Pathology and Laboratory Medicine

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Dan Theodorescu, MD, PhD

PHASE ONE Foundation Distinguished Chair

Director, Cedars-Sinai Cancer

Professor, Surgery

Professor, Pathology and Laboratory Medicine

Dan Theodorescu, MD, PhD, is the director of the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai. From 2010 until 2018, he was director of the University of Colorado Cancer Center and a distinguished university professor. Dr. Theodorescu is known for his work on the molecular mechanisms underlying bladder cancer and tools that determine drug response as well as the discovery of new drugs for cancer. Examples include the discovery of genes that regulate tumor growth and metastasis (RhoGDI2, AGL, GON4L), and novel biomarkers (DNA/NGS, RNA and proteomic) and concepts for precision therapeutic approaches such as the COXEN principle, which is being tested in national (SWOG) clinical trials. He also conceptualized the approach and then led the discovery and development of a "first in class" RalGTPase inhibitor as a new therapeutic in cancer. This drug was awarded a U.S. patent and is in commercial development. His laboratory is funded by grants from the NIH-NCI. Dr. Theodorescu has published over 300 articles including articles in Nature, Science, Cancer Cell, PNAS and JCI.

  • Medical School: Queen's University, Ontario, 1986
  • Internship: University of Toronto, 1987
  • Doctorate: University of Toronto, 1993
  • Residency: University of Toronto, 1994
  • Fellowship: Memorial Sloan-Kettering Cancer Center, 1995
  • Distinguished University Professor, University of Colorado, 2017
  • Peng Lecture, NYU School of Medicine, 2015
  • Barringer Medal, American Association of Genitourinary Surgeons, 2015
  • Hirschler Visiting Professor, University of Washington School of Medicine, 2015
  • Elected to National Academy of Medicine (NAM), United States of America (formerly known as the Institute of Medicine (IOM) of the National Academy of Science), 2014
  • Honorary Member Brazilian Cancer Society, 2014
  • Elected to American Surgical Association (ASA), 2012
  • Inventor of the Year, University of Colorado, 2011
  • Vincent J. O’Connor, Jr. Visiting Professor, Northwestern University Feinberg School of Medicine, 2011
  • Professor Emeritus, Department of Urology, University of Virginia, 2010

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Click here for a list of peer-reviewed publications.

  • Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H, Frierson HF. Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis. Lancet Oncol 2006; 7:230-40.
  • Lee JK, Havaleshko DM, Cho H, Weinstein JN, Kaldjian EP, Karpovich J, Grimshaw A, Theodorescu D. A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery. Proc Natl Acad Sci U S A 2007;104:13086-91.
  • Smith SC, Baras AS, Dancik G, Ru Y, Ding KF, Moskaluk CA, Fradet Y, Lehmann J, Stockle M, Hartmann A, Lee JK, Theodorescu D. A 20-gene model for molecular nodal staging of bladder cancer: development and prospective assessment. Lancet Oncol 2011;12:137-43.
  • Said N, Smith S, Sanchez-Carbayo M, Theodorescu D. Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer. J Clin Invest 2011;121:132-47.
  • Said N, Sanchez-Carbayo M, Smith SC, Theodorescu D. RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration. J Clin Invest 2012;122:1503-18.
  • Overdevest JB, Knubel KH, Duex JE, Thomas S, Nitz MD, Harding MA, Smith SC, Frierson HF, Conaway M, Theodorescu D. CD24 expression is important in male urothelial tumorigenesis and metastasis in mice and is androgen regulated. Proc Natl Acad Sci U S A 2012;109:E3588-96.
  • Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D. Discovery and characterization of small molecules that target the GTPase Ral. Nature 2014;515:443-7.

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