Jonathan Braun, MD, PhD
Jonathan Braun, MD, PhD
Jonathan Braun, MD, PhD, is a physician-researcher devoted to the roles of the immune system in resistance and susceptibility to inflammatory bowel disease and cancer. His recent national service includes chair of the National Scientific Advisory Committee of the Crohn's and Colitis Foundation; chair of the Scientific Board, Milieu Interieur, Institute Pasteur; president of the Clinical Immunology Society, and co-founder and president of the Federation of Clinical Immunology Societies, a leading international organization for translational immunology. Dr. Braun's research centers on the mechanisms of microbial-immune commensalism in the intestine and the integration of multi’omic and genetic analysis to advance the diagnosis and treatment of inflammatory bowel disease. The scope of this work includes functional immune assessment, tissue proteomics, genome-wide genetics, and microbiome metagenomics and metabolomics) and participation in the NIDDK IBD Genetics Consortium, NIH HMP2, and as PI of the CCFA Microbiome Consortium. His group is also devoted to new strategies in functional immune assessment, including gene targeting and positron-emission tomography for real-time imaging of immune-mediated inflammation. He has published more than 170 primary research studies, 14 issued patents, and co-founded three biotechnology companies.
- Undergraduate: Stanford University, 1975
- Doctorate: Harvard University, 1980
- Medical School: Harvard Medical School, 1981
- Residency: Brigham and Women's Hospital, 1985
- Post Doctorate: Whitehead Institute, 1985
Awards & Activities
- Leukemia Society Scholar Award, 1986
- Fellow, American Association for the Advancement of Science, 2001
- Fellow, American Gastroenterological Association, 2011
- Modell Award, Crohn's and Colitis Foundation of America, 2015
- Charles M. Mansbach, II, MD, Memorial Lecture. American Gastroenterological Association, 2018
- Sidney Truelove Lecture, International Organization for the Study of IBD (IOIBD), 2019
Click here for a list of peer-reviewed publications.
- Fu J, Wei B, Wen T, Johansson ME, Liu X, Bradford E, Thomsson KA, McGee S, Mansour L, Tong M, McDaniel JM, Sferra TJ, Turner JR, Chen H, Hansson GC, Braun J, Xia L. Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest. 2011;121:1657-1666.
- McHardy IH, Goudarzi M, Tong M, Ruegger PM, Schwager E, Weger JR, Graeber TG, Sonnenburg JL, Horvath S, Huttenhower C, McGovern DP, Fornace AJ, Jr., Borneman J, Braun J. Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships. Microbiome. 2013;1:17.
- Yamamoto ML, Maier I, Dang AT, Berry D, Liu J, Ruegger PM, Yang JI, Soto PA, Presley LL, Reliene R, Westbrook AM, Wei B, Loy A, Chang C, Braun J, Borneman J, Schiestl RH. Intestinal bacteria modify lymphoma incidence and latency by affecting systemic inflammatory state, oxidative stress, and leucocyte genotoxicity. Cancer Research. 2013 Jul 15;73(14):4222-4232.
- Tong M, McHardy I, Ruegger P, Goudarzi M, Kashyap PC, Haritunians T, Li X, Graeber TG, Schwager E, Huttenhower C, Fornace AJ, Jr., Sonnenburg JL, McGovern DP, Borneman J, Braun J. Reprogramming gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism. ISME J. 2014;8:2193-2206
- Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, D'Amato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, Kugathasan S, Büning C, Schumm LP, Klei L, Ananthakrishnan A, Aumais G, Baidoo L, Dubinsky M, Fiocchi C, Glas J, Milgrom R20, Proctor DD, Regueiro M, Simms LA, Stempak JM, Targan SR, Törkvist L, Sharma Y, Devlin B, Borneman J, Hakonarson H, Xavier RJ, Daly M, Brant SR, Rioux JD, Silverberg MS, Cho JH, Braun J, et al. A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition. Gastroenterology. 2016;151:724-732.
- Chang YL, Rossetti M, Vlamakis H, Casero D, Sunga G, Harre N, Miller S, R Humphries, Stappenbeck T, Simpson KW, Sartor RB, Wu G, Lewis J, Bushman F, McGovern DPB, Salzman N, Borneman J, Xavier R, Huttenhower C, Braun J. A screen of Crohn's disease-associated microbial metabolites identifies a novel metabolic inhibitor of activated human T cells. Mucosal Immunol. 2018 Apr 25. doi: 10.1038/s41385-018-0022-7. [Epub ahead of print]