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Kenneth Bernstein, MD

Professor, Pathology and Lab Medicine

Professor, Biomedical Sciences

Kenneth Bernstein, MD

Professor, Pathology and Lab Medicine

Professor, Biomedical Sciences

The Bernstein laboratory studies the renin-angiotensin system, a collection of proteins important in blood pressure control, heart disease and renal disease. Genetic models in mice are used to investigate the basic physiology and biochemistry of the renin-angiotensin system. The lab discovered important contributions of this system to hematopoiesis, reproduction, cancer immunology and lung injury, in addition to the cardiovascular system. In particular, the lab is investigating the possibility of manipulating this system as a means of increasing immune resistance.

View NIH Biographical Sketch as a PDF

  • Undergraduate: Dartmouth College, 1973
  • Medical School: New York University New York, 1978
  • Residency: Columbia University New York, 1980

View CV as a PDF

  • Distinguished Scientist, American Heart Association, 2013
  • Member, Association of American Physicians, 2009
  • Basic Research Prize of the American Heart Association, 2007
  • Co-recipient, AHA Novartis Prize for Hypertension Research, 2005

Click here for a list of peer-reviewed publications.

  • Bernstein KE, Koronyo Y, Salumbides B, Sheyn J, Pelissier L, Lopez DHL, Shah KH, Bernstein EA, Fuchs D-T, Yu J, et al. Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline. J Clin Invest. 2014;124(3):1000-1012. PMCID: PMC4312006
  • Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, Giani JF, Nguyen MT, Riquier-Brison AD, Seth DM, Fuchs S, Eladari D, Picard N, Bachmann S, Delpire E, Peti-Peterdi J, Navar LG, Bernstein KE, et al. The absence of intrarenal ACE protects against hypertension. J Clin Invest. 2013;123(5):2011-2023.
  • Khan Z, Shen XZ, Bernstein EA, Giani JF, Eriguchi M, Zhao T, Gonzalez-Villalobos RA, Fuchs S, Liu GY, Bernstein KE. Angiotensin converting enzyme (ACE) activity enhances bactericidal immunity of neutrophils. Blood. 2017 Jul 20;130(3):328-339. PMID: 28515091. PMCID: PMC5520468
  • Okwan-Duodu D, Datta V, Shen XZ, Goodridge HS, Bernstein EA, Fuchs S, Liu GY, Bernstein KE. Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus. J Biol Chem. 2010;285(50):39051-39060.
  • Shen XZ, Billet S, Lin C, Okwan-Duodu D, Chen X, Lukacher AE, Bernstein KE. The carboxypeptidase ACE shapes the MHC class I peptide repertoire. Nat Immunol. 2011 Oct 2;12(11):1078-1085.
  • Bernstein KE, Khan Z, Giani JF, Cao D-Y, Bernstein EA, Shen XZ. Angiotensin-converting enzyme (ACE) enhances the response of myeloid cells in innate and adaptive immunity. Nat Rev Nephrol. 2018 May;14(5):325-336. PMID:29578208.

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