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Tyler M. Pierson, MD

Assistant Professor, Medicine

Assistant Professor, Pediatrics

Cedars-Sinai
8700 Beverly Blvd.
North Tower, Suite 4221
Los Angeles, CA 90048

Phone:

310-423-4441

Fax:

310-423-1244

Parking Instructions:

Parking is available in front of Steven Spielberg Building in Lot 2.

Tyler M. Pierson, MD

Assistant Professor, Medicine

Assistant Professor, Pediatrics

  • Peds/Neurology
  • Pediatric Neurology & Neurosurgery

Ataxia

Cerebral Palsy

Muscular Dystrophy

Neurogenetics

Neuropathy

Seizure Disorders (Epilepsy)

Spasticity

Stroke (Cerebrovascular Accident) - CVA

The research of InfoTyler M Pierson, MD, focuses on Pediatric Neurogenetic Disorders. Pediatric Neurogenetic Disorders' diagnosis, disease models and therapeutic interventions biomedical research often focuses on common disorders that affect a significant portion of the population (e.g., diabetes, cancer, heart disease). This approach prudently allocates limited research funds toward disorders that have the most widespread effect on collective medical needs. Unfortunately, this path often neglects rare disorders that affect only a handful of patients, the study of which can be very valuable in providing insight into cellular and molecular functions. Rare neurogenetic disorders are often caused by genetic mutations that alter function of important genes involved in the development or function of cells in the central or peripheral nervous systems. Because many of the genes involved in these neurodevelopmental disorders are crucial to neurological development and human behavior, the effects of these disorders can often be observed early in life. Alternatively, pediatric neurodegenerative disorders can occur after normal neurodevelopment, with subsequent loss of motor and cognitive abilities. Consequently, pediatric neurogenetic disorders are a major subset of rare disorders, and many are severely debilitating and/or life-threatening.The recent emergence of genomic methods such as high-density single nucleotide polymorphism arrays, exome sequencing and whole-genome sequencing has revolutionized the ability to make diagnoses of rare or new disorders. Further advances in biotechnology, such as induced pluripotent stem cells, enables researchers to model these disorders with patient-derived cells to confirm the genetic diagnosis and research the mechanisms of disease.

View NIH Biographical Sketch as a PDF

  • Residency: Texas Children's Hospital, 2002
  • Residency: Hospital of the University of Pennsylvania, 2003
  • Fellowship: The Children's Hospital of Philadelphia, 2007
  • Post Doctorate: National Institutes of Health, 2012

View CV as a PDF

  • Fashion Industries Guild Endowed Fellowship for the Pediatric Undiagnosed Diseases, 2017
  • Fashion Industries Guild Endowed Fellowship in Pediatric Neuromuscular Diseases, 2012
  • National Human Genome Research Institute Merit Award
  • Team Science Award, Society for Clinical and Translational Science
  • NIH Intramural Loan Repayment Program Award
  • American Neurological Association Member
  • Member, American Academy of Neurology
  • Member, American Society of Gene and Cell Therapy
  • Member, Child Neurology Society
  • National Human Genome Research Institute Merit Award

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Click here for a list of peer-reviewed publications.

  • MG Otero, E Tiongson, F Diaz, K Haude, K Panzer, A Collier, J Kim, D Adams, CJ Tifft, H Cui, FM Zamora, MG Au, JM Graham Jr, DJ Buckley, R Lewis, C Toro, R Bai, L Turner, KD Mathews, W Gahl & TM Pierson. COX20 mutations causes early-onset sensory neuropathy, hypotonia, ataxia, and dystonia. Annals of Clinical and Translational Neurology. 2019;1: 154-160.
  • R Tripathy, I Leca, T van Dijk, B van Bon, T Gstrein, M Breuss, N Bahi-Buisson, A Paciorkowski, A Pagnamenta, J Taylor, G Terrone, G Vitiello, A D’Amico, E Del Giudice, N Brunetti-Pierri, A Reymond, N Voisin, JA Bernstein, E Farrelly, U Kini, T Leonard, L Armstrong, S Hiatt, G Cooper, G Mirzaa, TM Pierson, F Baas, J Chelly, NJ Cowan, DA Keays. Mutations in MAST1 cause mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Neuron. 2018;100:1354-1368
  • SK Sahai, R Steiner, MG Au, JM Graham, Jr., N Soloman, M Ibba, TM Pierson. FARS2 mutations presenting with pure spastic paraplegia and lesions of the dentate nuclei. Annals of Clinical and Translational Neurology. 2018;5:1128-1133
  • W Chen, C Shieh, JM Graham, M Tagliati, M Au, A Tankovic, W Wilcox, S Traynelis, H Yuan, and TM Pierson. GRIN1 mutation associated with developmental delay and movement disorder as a result of decreased NMDA receptor activity. Journal of Human Genetics. 2017;62:589-597
  • B Hjelm, C Grunseich, G Gowing, P Avalos, B Shelley, MA Mooney, K Narwani, Y Shi, CN Svendsen, JH Wolfe, KH Fischbeck, and TM Pierson. Mifepristone-inducible transgene expression in neural progenitor cells in vitro and in vivo. Gene Therapy. 2016;5:424-37
  • Yuan H, Hansen KB, Zhang J, Pierson TM, Markello TC, Fajardo KV, Holloman CM, Golas G, Adams DR, Boerkoel CF, et al. Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy. Nat Communications. 2014 ;5:3251.
  • Pierson TM, Yuan H, Marsh ED, Fuentes-Fajardo K, Adams DR, Markello T, Golas G, Simeonov DR, Holloman C, Tankovic A, et al. GRIN2A mutation and early-onset epileptic encephalopathy: personalized therapy with memantine. Annals of Clinical and Translational Neurology. 2014;1(3):190-198.
  • A Pizzino*, TM Pierson*, Y Guo, G Helman, S Fortini, K Guerrero, S Saitta, JLP Murphy, Q Padiath, Y Xie, H Hakonarson, X Xu, T Funari, M Fox, RJ Taft, MS van der Knaap, G Bernard, R Schiffmann, C Simons, A Vanderver. TUBB4A de novo mutations cause isolated hypomyelination. Neurology. 2014;83:898-902

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